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Counting chromosomes: Plant scientists solve a century-old mystery about reproduction

(Cold Spring Harbor Laboratory) Geneticists have solved a century-old mystery by discovering a remarkable mechanism that enables plants to count their chromosomes. Their ability to detect imbalances in male and female contributions to the next generation determines their progeny's viability and fertility.

Throwing molecular wrench into gene control machine leads to 'melting away' of leukemia

(Cold Spring Harbor Laboratory) Researchers have figured out a way to prevent MYB, one of the most potent cancer-aiding proteins, from activating genes in AML, an aggressive form of leukemia. Tested in mice, the new method resulted in dramatic cancer reduction and no harm to healthy cells. This could lead to a new therapy for AML and possibly other cancers.

New method to determine before surgery which prostate tumors pose a lethal threat

(Cold Spring Harbor Laboratory) A team at CSHL reports success in a small-scale test of a new analytical method to improve the early detection of potentially lethal prostate cancer. Based on diagnostic biopsy samples, the method promises to more accurately parse men who need surgery from those who do not.

New book on Cell-Cell Junctions published by CSHLPress

(Cold Spring Harbor Laboratory Press) "Cell-Cell Junctions, Second Edition", published by Cold Spring Harbor Laboratory Press, reviews our understanding of the organization, regulation, and dynamics of cell-cell junctions and the roles they play in morphogenesis, tissue homeostasis, and disease. Show More Summary

Fantastic journey: How newborn neurons to find their proper place in the adult brain

(Cold Spring Harbor Laboratory) This week in the Journal of Cell Biology, Professor Linda Van Aelst and colleagues at Cold Spring Harbor Laboratory (CSHL) describe for the first time (in mice) how baby neurons -- precursors called neuroblasts,...Show More Summary

Cryo-EM imaging suggests how the double helix separates during replication

(Cold Spring Harbor Laboratory) Figuring out how accurate replication works at the level of individual molecules and atoms is one of the great achievements of modern science. The journey of investigators is not yet done, however. A major unsolved part of the puzzle is understanding how the entire process of copying the genome begins. Show More Summary

Research revises our knowledge of how the brain learns to fear

(Cold Spring Harbor Laboratory) What happens in the brain when we learn that fire is very hot and can hurt us? It's the kind of learning that results from the association of a sensory stimulus and the perception of threat. New research...Show More Summary

New book on Cancer Evolution from Cold Spring Harbor Laboratory Press

(Cold Spring Harbor Laboratory Press) 'Cancer Evolution', from CSHLPress, examines cancer progression as an evolutionary process and explores how this way of looking at cancer may lead to more effective strategies for managing and treating it. Show More Summary

First cell-type census of mouse brains: Surprises about structure, male-female differences

(Cold Spring Harbor Laboratory) Neuroscientists at CSHL have mobilized advanced imaging and computational methods to comprehensively map -- 'count' -- the total populations of specific types of cells throughout the mouse brain. In aShow More Summary

Plant geneticists develop a new application of CRISPR to break yield barriers in crops

(Cold Spring Harbor Laboratory) Scientists at CSHL have harnessed the untapped power of genome editing to improve agricultural crops. In tomato they have mobilized CRISPR to rapidly generate variants of the plant displaying a continuum of three agriculturally important traits: fruit size, branching architecture and overall plant shape. Show More Summary

Plant geneticists develop a new application of CRISPR to break yield barriers in crops

Scientists at Cold Spring Harbor Laboratory (CSHL) have harnessed the still untapped power of genome editing to improve agricultural crops. Using tomato as an example, they have mobilized CRISPR/Cas9 technology to rapidly generate variants...Show More Summary

New book on Prion Biology from Cold Spring Harbor Laboratory Press

(Cold Spring Harbor Laboratory Press) 'Prion Biology', published by CSHLP, examines the expanding roles of prions in health and disease. The contributors review the structures of prion proteins and how they adopt alternative structures and aggregate into amyloid fibrils and other insoluble complexes. Show More Summary

New book on The Biology of the TGF-? Family from Cold Spring Harbor Laboratory Press

(Cold Spring Harbor Laboratory Press) "The Biology of the TGF-? Family" provides a comprehensive view of the different members of the TGF-? family, the signaling pathways they control, and how they influence development, normal physiology, and disease. Show More Summary

New book on Cell Polarity from Cold Spring Harbor Laboratory Press

(Cold Spring Harbor Laboratory Press) "Cell Polarity", published by Cold Spring Harbor Laboratory Press, reviews our understanding of the molecular mechanisms involved in establishing and maintaining cell polarity, as well as their relevance for human disorders. Show More Summary

New book on Tissue Engineering and Regenerative Medicine from CSHLPress

(Cold Spring Harbor Laboratory Press) "Tissue Engineering and Regenerative Medicine", published by Cold Spring Harbor Laboratory Press (CSHLP), surveys tools that are currently available to scientists and engineers in the field and how they have been used to fabricate physiologically appropriate tissues and organs. Show More Summary

New book on The Biology of Exercise from Cold Spring Harbor Laboratory Press

(Cold Spring Harbor Laboratory Press) "The Biology of Exercise", published by Cold Spring Harbor Laboratory Press, examines the biological basis of exercise from the molecular to the systemic levels. Contributors discuss how transcriptional...Show More Summary

New book on Targeting Cancer from Cold Spring Harbor Laboratory Press

(Cold Spring Harbor Laboratory Press) The 81st Cold Spring Harbor Symposium focused on Targeting Cancer. The implications of how the underlying science can drive improvements in diagnostic, prognostic, and therapeutic approaches was a major theme throughout the Symposium. Show More Summary

Tracking down the jumping genes of maize

(University of California - Davis) The "jumping genes" of maize have finally been mapped by an international team led by researchers at UC Davis and the Cold Spring Harbor Laboratory. The discovery could ultimately benefit the breeding and production of maize, one of the world's most important crops.

Tracking down the jumping genes of maize

The "jumping genes" of maize have finally been mapped by an international team led by researchers at the University of California, Davis, and the Cold Spring Harbor Laboratory. The discovery could ultimately benefit the breeding and production of maize, one of the world's most important crops.

Research reveals 'exquisite selectivity' of neuronal wiring in the cerebral cortex

(Cold Spring Harbor Laboratory) In a study appearing today in Nature Neuroscience, a team from Cold Spring Harbor Laboratory uses advanced technologies to illuminate the connectivity pattern of chandelier cells, a distinctive kind of inhibitory cell type in the mammalian brain. Show More Summary

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