(Cold Spring Harbor Laboratory) About 10 years ago, several labs discovered that a gene called MELK is overexpressed, or turned on to a high degree, in many cancer cell types. This evidence has prompted multiple ongoing clinical trials to test whether drugs that inhibit MELK can treat cancer in patients. Show More Summary
(Cold Spring Harbor Laboratory) A new study of the genetic factors involved in the causation of autism spectrum disorders (ASD) draws fresh attention to the impact these illnesses have on motor skills, and more broadly on cognitive function. Show More Summary
(PLOS) The Public Library of Science (PLOS) and Cold Spring Harbor Laboratory (CSHL) announce today an agreement that enables the automatic posting of research articles submitted to PLOS journals on bioRxiv, CSHL's preprint server for the life sciences.
(Cold Spring Harbor Laboratory) Rice provides 20% of daily calories consumed globally. We will need more as population grows toward 9-10 billion by 2050. A vast new genetic resource based on comparison of 13 rice genomes and published...Show More Summary
(Cold Spring Harbor Laboratory) Today, biologists add an important discovery to a growing body of data explaining why we're different from chimps and other primate relatives, despite the remarkable similarity of our genes. The new evidence has to do with the way genes are regulated. Show More Summary
(Cold Spring Harbor Laboratory) Geneticists have solved a century-old mystery by discovering a remarkable mechanism that enables plants to count their chromosomes. Their ability to detect imbalances in male and female contributions to the next generation determines their progeny's viability and fertility.
(Cold Spring Harbor Laboratory) Researchers have figured out a way to prevent MYB, one of the most potent cancer-aiding proteins, from activating genes in AML, an aggressive form of leukemia. Tested in mice, the new method resulted in dramatic cancer reduction and no harm to healthy cells. This could lead to a new therapy for AML and possibly other cancers.
(Cold Spring Harbor Laboratory) A team at CSHL reports success in a small-scale test of a new analytical method to improve the early detection of potentially lethal prostate cancer. Based on diagnostic biopsy samples, the method promises to more accurately parse men who need surgery from those who do not.
Cold Spring Harbor, NY - The facts about prostate cancer can be confusing. It's the third most common cancer type among Americans - 161,000 men will be diagnosed this year, the National Cancer Institute estimates. Yet according to the...Show More Summary
(Cold Spring Harbor Laboratory Press) "Cell-Cell Junctions, Second Edition", published by Cold Spring Harbor Laboratory Press, reviews our understanding of the organization, regulation, and dynamics of cell-cell junctions and the roles they play in morphogenesis, tissue homeostasis, and disease. Show More Summary
Cold Spring Harbor, NY - One of the most hopeful discoveries of modern neuroscience is firm proof that the human brain is not static following birth. Rather, it is continually renewing itself, via a process called postnatal neurogenesis - literally, the birth of new neurons. Show More Summary
(Cold Spring Harbor Laboratory) This week in the Journal of Cell Biology, Professor Linda Van Aelst and colleagues at Cold Spring Harbor Laboratory (CSHL) describe for the first time (in mice) how baby neurons -- precursors called neuroblasts,...Show More Summary
(Cold Spring Harbor Laboratory) Figuring out how accurate replication works at the level of individual molecules and atoms is one of the great achievements of modern science. The journey of investigators is not yet done, however. A major unsolved part of the puzzle is understanding how the entire process of copying the genome begins. Show More Summary
(Cold Spring Harbor Laboratory) What happens in the brain when we learn that fire is very hot and can hurt us? It's the kind of learning that results from the association of a sensory stimulus and the perception of threat. New research...Show More Summary
(Cold Spring Harbor Laboratory Press) 'Cancer Evolution', from CSHLPress, examines cancer progression as an evolutionary process and explores how this way of looking at cancer may lead to more effective strategies for managing and treating it. Show More Summary
(Cold Spring Harbor Laboratory) Neuroscientists at CSHL have mobilized advanced imaging and computational methods to comprehensively map -- 'count' -- the total populations of specific types of cells throughout the mouse brain. In aShow More Summary
(Cold Spring Harbor Laboratory) Scientists at CSHL have harnessed the untapped power of genome editing to improve agricultural crops. In tomato they have mobilized CRISPR to rapidly generate variants of the plant displaying a continuum of three agriculturally important traits: fruit size, branching architecture and overall plant shape. Show More Summary
Scientists at Cold Spring Harbor Laboratory (CSHL) have harnessed the still untapped power of genome editing to improve agricultural crops. Using tomato as an example, they have mobilized CRISPR/Cas9 technology to rapidly generate variants...Show More Summary
(Cold Spring Harbor Laboratory Press) 'Prion Biology', published by CSHLP, examines the expanding roles of prions in health and disease. The contributors review the structures of prion proteins and how they adopt alternative structures and aggregate into amyloid fibrils and other insoluble complexes. Show More Summary
(Cold Spring Harbor Laboratory Press) "The Biology of the TGF-? Family" provides a comprehensive view of the different members of the TGF-? family, the signaling pathways they control, and how they influence development, normal physiology, and disease. Show More Summary