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Science self-corrects: Cancer gene does not pass reproducibility test

(Cold Spring Harbor Laboratory) About 10 years ago, several labs discovered that a gene called MELK is overexpressed, or turned on to a high degree, in many cancer cell types. This evidence has prompted multiple ongoing clinical trials to test whether drugs that inhibit MELK can treat cancer in patients. Show More Summary

Autism genetics study calls attention to motor skills, general cognitive impairment

(Cold Spring Harbor Laboratory) A new study of the genetic factors involved in the causation of autism spectrum disorders (ASD) draws fresh attention to the impact these illnesses have on motor skills, and more broadly on cognitive function. Show More Summary

PLOS and Cold Spring Harbor Laboratory agree to enable preprint posting on bioRxiv

(PLOS) The Public Library of Science (PLOS) and Cold Spring Harbor Laboratory (CSHL) announce today an agreement that enables the automatic posting of research articles submitted to PLOS journals on bioRxiv, CSHL's preprint server for the life sciences.

More rice, please: 13 rice genomes reveal ways to keep up with ever-growing population

(Cold Spring Harbor Laboratory) Rice provides 20% of daily calories consumed globally. We will need more as population grows toward 9-10 billion by 2050. A vast new genetic resource based on comparison of 13 rice genomes and published...Show More Summary

Evolving sets of gene regulators explain some of our differences from other primates

(Cold Spring Harbor Laboratory) Today, biologists add an important discovery to a growing body of data explaining why we're different from chimps and other primate relatives, despite the remarkable similarity of our genes. The new evidence has to do with the way genes are regulated. Show More Summary

Counting chromosomes: Plant scientists solve a century-old mystery about reproduction

(Cold Spring Harbor Laboratory) Geneticists have solved a century-old mystery by discovering a remarkable mechanism that enables plants to count their chromosomes. Their ability to detect imbalances in male and female contributions to the next generation determines their progeny's viability and fertility.

Throwing molecular wrench into gene control machine leads to 'melting away' of leukemia

(Cold Spring Harbor Laboratory) Researchers have figured out a way to prevent MYB, one of the most potent cancer-aiding proteins, from activating genes in AML, an aggressive form of leukemia. Tested in mice, the new method resulted in dramatic cancer reduction and no harm to healthy cells. This could lead to a new therapy for AML and possibly other cancers.

New method to determine before surgery which prostate tumors pose a lethal threat

(Cold Spring Harbor Laboratory) A team at CSHL reports success in a small-scale test of a new analytical method to improve the early detection of potentially lethal prostate cancer. Based on diagnostic biopsy samples, the method promises to more accurately parse men who need surgery from those who do not.

New method to determine before surgery which prostate tumors pose a lethal threat

Cold Spring Harbor, NY - The facts about prostate cancer can be confusing. It's the third most common cancer type among Americans - 161,000 men will be diagnosed this year, the National Cancer Institute estimates. Yet according to the...Show More Summary

New book on Cell-Cell Junctions published by CSHLPress

(Cold Spring Harbor Laboratory Press) "Cell-Cell Junctions, Second Edition", published by Cold Spring Harbor Laboratory Press, reviews our understanding of the organization, regulation, and dynamics of cell-cell junctions and the roles they play in morphogenesis, tissue homeostasis, and disease. Show More Summary

Fantastic journey: How newborn neurons to find their proper place in the adult brain

Cold Spring Harbor, NY - One of the most hopeful discoveries of modern neuroscience is firm proof that the human brain is not static following birth. Rather, it is continually renewing itself, via a process called postnatal neurogenesis - literally, the birth of new neurons. Show More Summary

Fantastic journey: How newborn neurons to find their proper place in the adult brain

(Cold Spring Harbor Laboratory) This week in the Journal of Cell Biology, Professor Linda Van Aelst and colleagues at Cold Spring Harbor Laboratory (CSHL) describe for the first time (in mice) how baby neurons -- precursors called neuroblasts,...Show More Summary

Cryo-EM imaging suggests how the double helix separates during replication

(Cold Spring Harbor Laboratory) Figuring out how accurate replication works at the level of individual molecules and atoms is one of the great achievements of modern science. The journey of investigators is not yet done, however. A major unsolved part of the puzzle is understanding how the entire process of copying the genome begins. Show More Summary

Research revises our knowledge of how the brain learns to fear

(Cold Spring Harbor Laboratory) What happens in the brain when we learn that fire is very hot and can hurt us? It's the kind of learning that results from the association of a sensory stimulus and the perception of threat. New research...Show More Summary

New book on Cancer Evolution from Cold Spring Harbor Laboratory Press

(Cold Spring Harbor Laboratory Press) 'Cancer Evolution', from CSHLPress, examines cancer progression as an evolutionary process and explores how this way of looking at cancer may lead to more effective strategies for managing and treating it. Show More Summary

First cell-type census of mouse brains: Surprises about structure, male-female differences

(Cold Spring Harbor Laboratory) Neuroscientists at CSHL have mobilized advanced imaging and computational methods to comprehensively map -- 'count' -- the total populations of specific types of cells throughout the mouse brain. In aShow More Summary

Plant geneticists develop a new application of CRISPR to break yield barriers in crops

(Cold Spring Harbor Laboratory) Scientists at CSHL have harnessed the untapped power of genome editing to improve agricultural crops. In tomato they have mobilized CRISPR to rapidly generate variants of the plant displaying a continuum of three agriculturally important traits: fruit size, branching architecture and overall plant shape. Show More Summary

Plant geneticists develop a new application of CRISPR to break yield barriers in crops

Scientists at Cold Spring Harbor Laboratory (CSHL) have harnessed the still untapped power of genome editing to improve agricultural crops. Using tomato as an example, they have mobilized CRISPR/Cas9 technology to rapidly generate variants...Show More Summary

New book on Prion Biology from Cold Spring Harbor Laboratory Press

(Cold Spring Harbor Laboratory Press) 'Prion Biology', published by CSHLP, examines the expanding roles of prions in health and disease. The contributors review the structures of prion proteins and how they adopt alternative structures and aggregate into amyloid fibrils and other insoluble complexes. Show More Summary

New book on The Biology of the TGF-? Family from Cold Spring Harbor Laboratory Press

(Cold Spring Harbor Laboratory Press) "The Biology of the TGF-? Family" provides a comprehensive view of the different members of the TGF-? family, the signaling pathways they control, and how they influence development, normal physiology, and disease. Show More Summary

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