It arises from what scientists previously described as "junk DNA" or "the dark matter of the genome," but this gene is definitely not junk. The gene GAS5 acts as a brake on steroid hormone receptors, making it a key player in diseases such as hormone-sensitive prostate and breast cancer. read more
A big dispute erupted in the genomics world in 2012 with the publication of the ENCODE consortium's data - and with their interpretation of it. How much of the human genome is functional? And just what does "functional" mean? The ENCODE...Show More Summary
A team has mined genomic sequences sequences to identify a non-protein-coding RNA whose expression is linked to ovarian cancer.
PHILADELPHIA - Over the years researchers have made tremendous strides in the understanding and treatment of cancer by searching genomes for links between genetic alterations and disease. read more
More than a decade has passed since the completion of the Human Genome Project, the international collaboration to map all of the "letters" in our DNA. The huge effort led to revolutionary genomic discoveries, but more than 10 yearsShow More Summary
Geneticists at Oxford University are making the astounding claim that a mere 8.2% of our DNA does something biologically important. That means upwards of 90% of the human genome is "junk" — a discovery that could dramatically hasten genetic research. Read more...
Only 8.2 percent of human DNA is likely to be doing something important -- is 'functional' -- say researchers. This figure is very different from one given in 2012, when some scientists involved in the ENCODE (Encyclopedia of DNA Elements) project stated that 80% of our genome has some biochemical function.
This is the paper to read: Palazzo & Gregory’s The Case for Junk DNA. It clearly and logically lays out the complete argument from evidence and theory for the thesis that most of the genome is junk. It’s not revolutionary or radical, though: the whole story is based on very fundamental population genetics and molecular…
Science: The “Hypothetical Protein” Problem (excellent) Improving air quality in NYC would boost children’s future earnings by increasing IQ The Case for Junk DNA A Week of Irony Denmark: Three Deaths from Drug-Resistant “Pig MRSA” Other: The problem with Thomas … Continue reading ?
The term "junk DNA" has been under attack lately, but a pair of geneticists are now making the case for this much maligned and misunderstood concept. There are significant chunks of our DNA, they argue, that really are utterly useless. Read more...
Large sections of the genome that were once referred to as 'junk' DNA have been linked to human heart failure, according to research. So-called junk DNA was long thought to have no important role in heredity or disease because it doesn't code for proteins. Show More Summary
Large sections of the genome that were once referred to as "junk" DNA have been linked to human heart failure, according to research from Washington University School of Medicine in St. Louis. So-called junk DNA was long thought to have no important role in heredity or disease because it doesn't code for proteins. Show More Summary
In 2007, a PLoS ONE paper by Ahmed et al. proposed a phylogeny for Mycobacteria in which M. leprae (the leprosy organism) is shown as a relatively recent branch off a very long tree, with M. tuberculosis depicted (in a decidedly fanciful schematic) as being of relatively recent provenance (35,000 years), diverging from M. Show More Summary
Undergrads in "Build-A-Genome" class help get rid of all the junk DNA.
Once thought of as "junk" DNA because it does not contain genes that encode proteins, scientists are starting to discover non-coding DNA can nevertheless influence the effect of coding DNA, such as switching genes on and off.Now, a new...Show More Summary
Variations in non-coding sections of the genome might be important contributors to type 2 diabetes risk, according to a new study. DNA sequences that don't encode proteins were once dismissed as "junk DNA", but scientists are increasingly...Show More Summary
Stretches of DNA called retrotransposons, often dubbed "junk DNA", might play an important role in schizophrenia. In a study published today in the journal Neuron, a Japanese team revealed that LINE-1 retrotransposons are abnormallyShow More Summary
Stretches of DNA called retrotransposons, often dubbed “junk DNA”, might play an important role in schizophrenia. In a study published, a Japanese team revealed that LINE-1 retrotransposons are abnormally abundant in the schizophrenia brain, modify the expression of genes related to schizophrenia during brain development, and may be one of the causes of schizophrenia.
Even as whole-genome sequencing has become much cheaper, genetic research has continued to focus on the exome, or the tiny fraction of human DNA that codes the proteins that make up our physical structures. But according to a recentShow More Summary