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Frequent, personalized CA125 testing may help detect ovarian cancer in high-risk women

(Massachusetts General Hospital) The combined results of two ovarian cancer screening trials suggest that a personalized strategy involving frequent screening of high-risk women could improve the chance that tumors are detected at early stages when they are easier to treat.

Clinical trial supports use of novel preventive therapy for dangerous swelling disorder

(Massachusetts General Hospital) A clinical trial for a new drug to prevent attacks of hereditary angioedema -- a rare disorder characterized by recurrent swelling of tissues in the face, hands, gastrointestinal tract and airway -- has had promising results.

Molecular 'on switch' could point to treatments for pediatric brain tumor

(Massachusetts General Hospital) Massachusetts General Hospital researchers have identified a mechanism that controls the expression of genes regulating the growth of the most aggressive form of medulloblastoma, the most common pediatric brain tumor.

Study confirms vitamin D protection against cold and flu

(Massachusetts General Hospital) A new global collaborative study has confirmed that vitamin D supplementation can help protect against acute respiratory infections. The study, a participant data meta-analysis of 25 randomized controlled trials including more than 11,000 participants, has been published online in The BMJ.

Women in academic cardiology are significantly less likely to be full professors

(Massachusetts General Hospital) The first study to evaluate sex differences in academic ranking among academic cardiologists has found that women were significantly less likely than men to be full professors, even when adjusting for factors such as age, years of experience and research productivity that are traditionally associated with academic rank.

Advanced EEG analysis reveals the complex beauty of the sleeping brain

(Massachusetts General Hospital) Massachusetts General Hospital investigators have developed a novel approach to analyze brainwaves during sleep, which promises to give a more detailed and accurate depiction of neurophysiological changes than provided by a traditional sleep study.

Low-dose chemotherapy protocol relies on normalization of tumor blood supply

(Massachusetts General Hospital) The effects of a promising new approach to chemotherapy that involves frequent administration of dosage levels much lower than traditionally used appears to rely on the 'normalization' of blood vessels within and around a tumor.

Adding antiandrogen to radiation therapy improves survival in recurrent prostate cancer

(Massachusetts General Hospital) A nearly two-decades-long clinical trial has demonstrated that adding antiandrogen therapy to radiation therapy can improve the survival of prostate cancer patients who have evidence of disease recurrence after radical prostatectomy.

Travel restrictions 'a step backward' for US medical education, research and health care

(Massachusetts General Hospital) The executive order restricting individuals from seven Muslim-majority countries from entering the US is 'a step backward,' for medical education, patient care and biomedical research in this country, write medical department leaders from Massachusetts General Hospital and six other major academic medical centers.

Hormone may offer new contraceptive that protects ovaries from chemotherapy

(Massachusetts General Hospital) A team from the Massachusetts General Hospital Pediatric Surgical Research Laboratories reports that a naturally occurring hormone that plays an important role in fetal development may be the basis for a reversible contraceptive that can protect ovaries from the damage caused by chemotherapy.

A Better Carrier

Harvard Medical School scientists and colleagues from the Massachusetts General Hospital have partly restored hearing in mice with a genetic form of deafness. Scientists altered a common virus, enhancing its ability to enter hair cells...Show More Summary

New gene-delivery therapy restores partial hearing, balance in deaf mice

(Harvard Medical School) Using a novel form of gene therapy, scientists from Harvard Medical School and the Massachusetts General Hospital have managed to restore partial hearing and balance in mice born with a genetic condition that affects both.

Model assessment may predict obstructive sleep apnea in children with Down syndrome

(Massachusetts General Hospital) A combination of parental questionnaires and inexpensive diagnostic procedures that can be performed as part of a primary care visit may be able to rule out the presence of obstructive sleep apnea in people with Down syndrome.

Novel radiotracer measures olfactory neurons in animal models

(Massachusetts General Hospital) Olfactory health - how well we are able to smell -- is a reliable marker of the health of the brain, but current 'smell identification tests' do not offer a complete picture of the situation. Using aShow More Summary

Tracking movement of immune cells identifies key first steps in inflammatory arthritis

(Massachusetts General Hospital) Using a novel approach for imaging the movement of immune cells in living animals, researchers from the Massachusetts General Hospital Center for Immunology and Inflammatory Diseases have identified what appear to be the initial steps leading to joint inflammation in a model of inflammatory arthritis.

Public health experts support federally mandated smoke-free public housing

(Massachusetts General Hospital) In response to a new federal rule mandating smoke-free policies in federally funded public housing authorities, three public health experts applaud the efforts of the US Department of Housing and Urban Development to protect nonsmoking residents from the harmful effects of tobacco exposure.

Digital assay of circulating tumor cells may improve diagnosis, monitoring of liver cancer

(Massachusetts General Hospital) Use of an advanced form of the commonly used polymerase chain reaction method to analyze circulating tumor cells may greatly increase the ability to diagnose early-stage cancer, increasing the likelihood of successful treatment.

Changes in blood-brain barrier, intestinal permeability found in individuals with autism

(Massachusetts General Hospital) A Massachusetts General Hospital study finds reduced expression of genes involved in integrity of the blood-brain barrier, intestinal barrier in those with autism spectrum disorder.

High stress activity in the brain may indicate heart attack, stroke risk in future

High stress activity in the brain may indicate a future risk of heart attack and stroke, according to new research. Ahmed Tawakol of Massachusetts General Hospital coauthored the recent study, which found that those with a higher level...Show More Summary

Massachusetts General researchers identify new target for cancer immunotherapy

(Massachusetts General Hospital) Massachusetts General Hospital investigators have found new evidence that the tumor necrosis factor receptor type II may be a major target for immuno-oncology treatments, which induce a patient's immune system to fight cancer.

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