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Gluten-free diet may not reduce intestinal damage in all children with celiac disease

(Massachusetts General Hospital) In surprising findings, researchers from MassGeneral Hospital for Children (MGHfC) and Boston Children's Hospital (BCH) have discovered that nearly one in five children with celiac disease sustained persistent intestinal damage, despite strict adherence to a gluten-free diet.

New ways to measure solid stress in tumors could lead to improved understanding, therapies

(Massachusetts General Hospital) Massachusetts General Hospital investigators have developed new methods for mapping and measuring solid stress -- the force exerted by solid and elastic components -- within tumors, an accomplishment that may lead to improved understanding of those forces and their consequences and to novel treatment strategies.

Largest resource of human protein-protein interactions can help interpret genomic data

(Massachusetts General Hospital) An international research team has developed the largest database of protein-to-protein interaction networks, a resource that can illuminate how numerous disease-associated genes contribute to disease development and progression.

Aspartame may prevent, not promote, weight loss by blocking intestinal enzyme's activity

(Massachusetts General Hospital) A team of Massachusetts General Hospital investigators has found a possible mechanism explaining why use of the sugar substitute aspartame might not promote weight loss. The researchers describe how the aspartame breakdown product phenylalanine interferes with the action of an enzyme previously shown to prevent metabolic syndrome.

Palliative care helpful for cancer patients receiving bone marrow transplants

(Massachusetts General Hospital) Integrating palliative care into the treatment of patients undergoing hematopoietic stem cell transplantation - commonly known as bone marrow transplantation -- for cancers like leukemia and lymphoma can improve their quality of life, relieve symptoms associated with the procedure, and reduce depression and anxiety.

Targeted therapy drugs could radically increase the costs of leukemia treatment

(Massachusetts General Hospital) A study by a Massachusetts General Hospital-led research team finds that, at current prices, adoption of novel oral targeted therapies for treatment of chronic lymphocytic leukemia could raise the treatment costs for the blood-system cancer in the US by almost 600 percent.

U.S. surgeon general issues 'a new call to action' on addiction

When Dr. Vivek Murthy left his Massachusetts hospital three years ago to become U.S. surgeon general, the nurses who had known him since he was a resident had a parting plea: Do something about addiction. On Thursday, with his tenure nearing an end, Murthy tried to make good on that request with...

Ability to recognize and recall odors may identify those at risk for Alzheimer's disease

(Massachusetts General Hospital) A noninvasive protocol developed by Massachusetts General Hospital investigators that tests the ability to recognize, remember and distinguish between odors was able to identify older individuals who -- according to genetic, imaging and more detailed memory tests -- were at increased risk of Alzheimer's disease.

Study finds following a healthy lifestyle can greatly reduce genetic heart attack risk

(Massachusetts General Hospital) A study led by Massachusetts General Hospital investigators has found that, even among those at high genetic risk for heart disease, following a healthy lifestyle can cut in half the probability of a heart attack or similar event.

Molecular signature for aggressive brain tumor uncovered

(Brigham and Women's Hospital) Researchers from Brigham and Women's Hospital, in collaboration with colleagues at Massachusetts General Hospital, have identified genetic mutations that can distinguish aggressive rhabdoid meningiomas from more benign forms using routine laboratory tests.

Presurgical endocrine therapy less toxic than chemotherapy for ER-positive breast cancer

(Massachusetts General Hospital) Neoadjuvant endocrine therapy -- designed to reduce the size of breast tumors before surgical removal -- appears to be as effective as neoadjuvant chemotherapy for patients with localized, estrogen-receptor (ER)-positive breast cancer with considerably fewer side effects.

MIT-led group uses machines to fix vocal problems

An MIT and Massachusetts General Hospital group believes that machine learning can play a role in better understanding speech disorders and correcting vocal issues. The team recently described using a wearable gadget to gather accelerometer data to determine differences in people with Muscle Tension Dysphonia (MTD) compared to a control group. Show More Summary

New imaging technique stimulates particles to emit laser light, could create higher-resolution images

A new imaging technique developed by scientists at MIT, Harvard University, and Massachusetts General Hospital (MGH) aims to illuminate cellular structures in deep tissue and other dense and opaque materials. Their method uses tiny particles embedded in the material, that give off laser light.

Smoking may shorten the lifespan of people living with HIV more than HIV itself

(Massachusetts General Hospital) A new study led by researchers at Massachusetts General Hospital finds that cigarette smoking substantially reduces the lifespan of people living with HIV in the US, potentially even more than HIV itself.

Single-cell analysis supports a role for cancer stem cells in brain tumor growth

(Massachusetts General Hospital) A study analyzing brain tumor genomics on a single-cell level has found evidence that cancer stem cells fuel the growth of oligodendrogliomas, a slow-growing but incurable form of brain cancer.

Stimulation of dopamine neurons induces arousal of mice receiving general anesthesia

(Massachusetts General Hospital) The latest study from a Massachusetts General Hospital (MGH)/Massachusetts Institute of Technology (MIT) team investigating the mechanisms underlying general anesthesia finds that stimulating a specific group of neurons in mice produces signs of arousal even as the animals continue to receive the anesthetic drug isoflurane.

Study suggests approach to waking patients after surgery

(Massachusetts Institute of Technology) Researchers at MIT and Massachusetts General Hospital have moved a step closer to a treatment to rapidly awaken patients after administration of a general anesthetic, following a study of the mechanism that allows people to regain consciousness.

Advanced analysis of brain structure shape may track progression to Alzheimer's disease

(Massachusetts General Hospital) Use of a novel approach to analyzing brain structure that focuses on the shape rather than the size of particular features may allow identification of individuals in early presymptomatic stages of Alzheimer's disease.

Algorithm could help analyze fetal scans to determine whether interventions are warranted

Researchers from MIT, Boston Children's Hospital, and Massachusetts General Hospital have joined forces in an ambitious new project to use magnetic resonance imaging (MRI) to evaluate the health of fetuses.

Signaling pathway could be key to improved osteoporosis treatment

(Massachusetts General Hospital) A molecular signaling pathway identified by an international research team could be the basis of improved treatment for osteoporosis. In their report, the investigators describe how suppressing the activity of a specific enzyme not only increased bone formation in mice but also reduced levels of the cells responsible for bone breakdown.

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