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Stimulation of dopamine neurons induces arousal of mice receiving general anesthesia

(Massachusetts General Hospital) The latest study from a Massachusetts General Hospital (MGH)/Massachusetts Institute of Technology (MIT) team investigating the mechanisms underlying general anesthesia finds that stimulating a specific group of neurons in mice produces signs of arousal even as the animals continue to receive the anesthetic drug isoflurane.

Study suggests approach to waking patients after surgery

(Massachusetts Institute of Technology) Researchers at MIT and Massachusetts General Hospital have moved a step closer to a treatment to rapidly awaken patients after administration of a general anesthetic, following a study of the mechanism that allows people to regain consciousness.

Advanced analysis of brain structure shape may track progression to Alzheimer's disease

(Massachusetts General Hospital) Use of a novel approach to analyzing brain structure that focuses on the shape rather than the size of particular features may allow identification of individuals in early presymptomatic stages of Alzheimer's disease.

Algorithm could help analyze fetal scans to determine whether interventions are warranted

Researchers from MIT, Boston Children's Hospital, and Massachusetts General Hospital have joined forces in an ambitious new project to use magnetic resonance imaging (MRI) to evaluate the health of fetuses.

Signaling pathway could be key to improved osteoporosis treatment

(Massachusetts General Hospital) A molecular signaling pathway identified by an international research team could be the basis of improved treatment for osteoporosis. In their report, the investigators describe how suppressing the activity of a specific enzyme not only increased bone formation in mice but also reduced levels of the cells responsible for bone breakdown.

Scientists Are Growing New Hearts in the Shells of Old Ones

A recelluarized heart. (Photo: Bernhard Jank, M.D., Ott Lab, Massachusetts General Hospital) For decades now, there's been an image of human regeneration being a few cells dividing in a petri dish, hopefully growing into a shiny new organ. Show More Summary

MGH team identifies possible mechanism for resistance to antiangiogenesis therapy

(Massachusetts General Hospital) Massachusetts General Hospital investigators have identified a potential mechanism behind the resistance that inevitably develops to cancer treatment with a combination of chemotherapy and antiangiogenic drugs.

Different brain atrophy patterns may explain variability in Alzheimers disease symptoms

(Massachusetts General Hospital) Mathematical modeling of the brain scans of patients with Alzheimer's disease and others at risk for the devastating neurodegenerative disorder has identified specific patterns of brain atrophy that appear to be related to the loss of particular cognitive abilities.

Bacterial molecule trains the immune system to tolerate infection without inducing illness

(Massachusetts General Hospital) A study from Massachusetts General Hospital investigators has identified a mechanism leading to immune system tolerance of a common, difficult-to-treat bacteria by means of small molecule usually used by the pathogen to monitor its presence in the environment.

Studies address improving care for Chinese American immigrants with depression

(Massachusetts General Hospital) Two recent studies led by Massachusetts General Hospital psychiatrists have investigated ways of improving the treatment of depression in Chinese American immigrants, a group that tends to avoid mental health treatment because of traditional cultural beliefs.

Massachusetts General-led team to investigate impact of airway microbiome on childhood asthma

(Massachusetts General Hospital) A multi-institutional research team led by a Massachusetts General Hospital investigator is among the recipients of new National Institutes of Health grants through the Environmental influences on Child Health Outcomes initiative. Show More Summary

Antibody function may help keep tuberculosis infection under control

(Massachusetts General Hospital) A study led by investigators from the Ragon Institute of MGH, MIT and Harvard finds evidence that antibody protection may help control infection with the bacteria that causes tuberculosis. The findings...Show More Summary

Avoiding hospitalization for certain low-risk acute medical conditions appears safe

(Massachusetts General Hospital) A comprehensive review of studies evaluating strategies for treating certain acute medical conditions without hospital admission finds that all four evaluated strategies appear to be safe, often improve patient and caregiver satisfaction, and reduce health care costs.

New strategy identified for treating acute myeloid leukemia

(Massachusetts General Hospital) A multi-institutional academic and industry research team led by investigators from Massachusetts General Hospital and the Harvard Stem Cell Institute has identified a promising new approach to the treatment of acute myeloid leukemia

Teens With Bipolar Disorder at Increased Risk of Substance Use Disorder

Teens with bipolar disorder are at increased risk of substance use disorder as they get older, a study by researchers at Massachusetts General Hospital has found. The post Teens With Bipolar Disorder at Increased Risk of Substance Use Disorder appeared first on Partnership for Drug-Free Kids.

JDRF Partners to Protect Therapeutic Cells with Sernova’s “Cell Pouch”

JDRF partners with Sernova Corp. and their Cell Pouch and Massachusetts General Hospital’s Novel Immune Protection Technology to protect therapeutic cells in a new treatment of insulin dependent diabetes. Sernova Corp. is developingShow More Summary

How Well Does Brain Structure Predict Behaviour?

To what extent does brain structure correlate with different psychological traits? An interesting new paper from Massachusetts General Hospital researchers Mert R. Sabuncu and colleagues uses a new method to examine what the authors call the 'morphometricity' of various behaviours and mental disorders. Sabuncu et al. Show More Summary

Study suggests how 'super aging' older adults retain youthful memory abilities

Some loss of memory is often considered an inevitable part of aging, but new research reveals how some people appear to escape that fate. A study by Massachusetts General Hospital (MGH) investigators examines a remarkable group of older...Show More Summary

International studies identify 44 novel gene sites associated with hypertension risk

(Massachusetts General Hospital) In papers receiving advance online publication in Nature Genetics, two international multi-institutional research teams co-led by investigators at Massachusetts General Hospital describe identifying a total of 44 novel gene sites associated with hypertension or high blood pressure.

Scientists reveal insights into treatment resistance of metastastic breast cancer research

(Bethesda, MD, Sept. 06, 2016) - A prominent physician scientist supported by the National Foundation of Cancer Research (NFCR), Dr. Daniel Haber, and his team at the Massachusetts General Hospital Cancer Center have identified a dynamic...Show More Summary

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