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Novel DNA vaccine design improves chances of inducing anti-tumor immunity

Scientists have devised a novel DNA vaccine approach through molecular design to improve the immune responses elicited against one of the most important cancer antigen targets.

Watch the Master Microfixer Jessa Jones at Work

With a background in molecular genetics, the head of iPad Rehab leads a team of mostly women who fix severely damaged iPhones and iPads, even without manufacturer support.

Molecular 'on switch' could point to treatments for pediatric brain tumor

(Massachusetts General Hospital) Massachusetts General Hospital researchers have identified a mechanism that controls the expression of genes regulating the growth of the most aggressive form of medulloblastoma, the most common pediatric brain tumor.

Jessa Jones: Master Microfixer

Using her background in molecular genetics, Jessa Jones has pioneered a new form of board-level iPhone repair. She's teaching the world to fix devices that no one, not even Apple, thought it was possible to fix.

New structural studies reveal workings of a molecular pump that ejects cancer drugs

Sometimes cells resist medication by spitting it back out. Cancer cells, in particular, have a reputation for defiantly expelling the chemotherapy drugs meant to kill them. Researchers at The Rockefeller University have shed new light on a molecular pump that makes this possible, by determining its three-dimensional structure, down to the level of atoms.

New structural studies reveal workings of a molecular pump that ejects cancer drugs

(Rockefeller University) Sometimes cells spit out things we don't want them to--like medications. Researchers have determined the three-dimensional structure of a tiny pump that expels, among other things, chemotherapy agents. This new knowledge could lead to the design of more effective drugs.

A novel DNA vaccine design improves chances of inducing anti-tumor immunity

(The Wistar Institute) Scientists at The Wistar Institute and Inovio Pharmaceuticals, Inc. have devised a novel DNA vaccine approach through molecular design to improve the immune responses elicited against one of the most important cancer antigen targets.

Medical News Today: Alzheimer's disease: Molecular study clarifies potential link to high blood sugar

Sugar can damage cell proteins via glycation. Now, study finds glycation damage in enzyme for immune function and insulin regulation in early Alzheimer's.

Excess sugar linked to Alzheimer's in new study

3 days agoTechnology / Gadgets : Gizmag

You already know that sugar isn't the best thing for your health, but new research out of England might just give you another reason to avoid the white stuff. Scientists there say they've discovered a molecular link between blood sugar...Show More Summary

How proteins reshape cell membranes

(Max Delbrück Center for Molecular Medicine in the Helmholtz Association) Small 'bubbles' frequently form on membranes of cells and are taken up into their interior. The process involves EHD proteins -- a focus of research by Prof. Oliver Daumke of the MDC. He and his team have now shed light on how these proteins assemble on the surface of a cell and reshape its membrane.

Penn Study Finds Sons of Cocaine-Using Fathers Have Profound Memory Impairments

Fathers who use cocaine at the time of conceiving a child may be putting their sons at risk of learning disabilities and memory loss. The findings of the animal study were published online in Molecular Psychiatry by a team of researchers from the Perelman School of Medicine at the University of Pennsylvania.

Direct-to-consumer genomics: Harmful or empowering?

(Saint Louis University) In a recent paper, Joel Eissenberg, Ph.D., professor of biochemistry and molecular biology at Saint Louis University, explores questions that stem from new advances in direct-to-consumer DNA tests, which have the effect of separating the physician-patient relationship from access to new personal health data.

Sugar's 'tipping point' link to Alzheimer's disease revealed

(University of Bath) For the first time a molecular 'tipping point' has been demonstrated in Alzheimer's, linking high blood sugar with this debilitating disease

Dating the undatables

(Molecular Biology and Evolution (Oxford University Press)) New research recently published in the scientific journal, Molecular Biology and Evolution, by a team of scientists from Ireland and India resolved a 195-year old confusionShow More Summary

Researchers find insight into the simplest substitution reaction via Walden inversion mechanism

(Chinese Academy of Sciences Headquarters) A research term led by Prof. ZHANG Donghui from State Key Laboratory of Molecular Reaction Dynamics of Dalian Institute of Chemical Physics has carried out an accurate quantum dynamics study of the H' + CH4 ¡ú CH3H' + H substitution reaction and its isotope analogies. Show More Summary

CRISPR Will Never Be Good Enough To Improve People

The CRISPR/Cas9 (CRISPR) technique has been used to modify genes in animals, plants and fungi, organisms different from and more complex than the bacteria in which the molecular components originally evolved. It has undergone several refinements since its introduction, each iteration proving more accurate, with fewer off-target effects. Show More Summary

Clinical Practice Guideline Focuses on Molecular Biomarker Testing for Patients with Colorectal Cancer

A new, evidenced-based clinical practice guideline on molecular biomarker testing for patients with colorectal cancer identifies opportunities for improving patient outcomes.

Molecular biology: RNA editing packs a one-two punch

4 days agoAcademics : Nature

Optimal protein synthesis requires bases in transfer RNAs to be modified. A key modification has been shown to involve an unusual two-step mechanism that entails the sequential activities of two enzymes. See Letter p.494

Immunology: The chronicles of T-cell exhaustion

4 days agoAcademics : Nature AOP

T cells of the immune system often fail to target cancer cells because they enter a dysfunctional state known as exhaustion. Molecular analysis of T-cell exhaustion provides insights into the clinical use of these cells.

New method helps researchers piece together the puzzle of antibiotic resistance

Researchers from The University of Queensland's Institute for Molecular Bioscience (IMB) have developed a faster and more accurate method for assembling genomes which could help clinicians rapidly identify antibiotic-resistant infections.

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