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American Red Cross holding blood drive in Cypress

Continuing its holiday season blood drives, the American Red Cross will be in Cypress from 9 a.m. to 3 p.m. Wednesday, Dec. 13, at DiaSorin Molecular, 11331 Valley View St. For information or to schedule a blood donation appointment, call 800-733-2767 or visit redcrossblood.org. Alicia Robinson, 714-796-7724 arobinson@scng.com

Typhoid fever toxin has a sweet tooth

(Cornell University) Although the insidious bacterium Salmonella typhi has been around for centuries, very little is actually known about its molecular mechanisms. A new study from researchers at the College of Veterinary Medicine addresses this knowledge gap and may lead to novel, targeted treatments.

Searching for the CRISPR Swiss-army knife

(FECYT - Spanish Foundation for Science and Technology) Scientists at the University of Copenhagen, led by the Spanish Professor Guillermo Montoya, are investigating the molecular features of different molecular scissors of the CRISPR-Cas system to shed light on the so-called 'Swiss-army knives' of genome editing. Show More Summary

The initial mass function

The gas and dust in giant molecular clouds gradually come together under the influence of gravity to form stars. Precisely how this occurs, however, is incompletely understood. The mass of a star, for example, is by far the most important...Show More Summary

New online database brings the genome into focus using molecular structure

Iowa State University researchers have built an accessible online database that brings critical genomic data into sharp focus with the single click of a mouse.

Study shows combining chemotherapy with targeted drug boosts response in chronic lymphocytic leukemia

(Dana-Farber Cancer Institute) Among younger patients newly diagnosed with chronic lymphocytic leukemia (CLL), treatment with a combination of chemotherapy and a molecularly targeted drug significantly improves response over what is typically seen with chemotherapy alone, according to an investigator-initiated multi-center phase II clinical trial.

New assay may help predict which pancreatic lesions may become cancerous

A new report describes a new simple molecular test to detect chromosomal abnormalities -- biomarkers known as telomere fusions -- in pancreatic tumor specimens and pancreatic cyst fluids. This assay may help predict the presence of high-grade or invasive pancreatic cancers requiring surgical intervention.

Molecular beacon signals low oxygen with ultrasound

Areas of hypoxia, or low oxygen in tissue, are hallmarks of fast-growing cancers and of blockages or narrowing in blood vessels, such as stroke or peripheral artery disease. University of Illinois researchers have developed a way to find hypoxic spots noninvasively in real time.

Novel pathway to suppress virus-induced cancers

Researchers have identified a novel molecular pathway by which a tumor suppressor, TIP60, inhibits the growth of cancer cells. The study paves the way for the development of new therapeutic strategies that could impede the spread of virus-induced cancers.

Molecular beacon signals low oxygen with ultrasound

(University of Illinois at Urbana-Champaign) Areas of hypoxia, or low oxygen in tissue, are hallmarks of fast-growing cancers and of blockages or narrowing in blood vessels, such as stroke or peripheral artery disease. University of Illinois researchers have developed a way to find hypoxic spots noninvasively in real time. Show More Summary

Structure of channelrhodopsin determined

Researchers discover structure and mechanism of action of molecular light switch, paving the way for new applications

Understanding Earth's geologic history to predict the future

Pratigya Polissar is an organic geochemist at Lamont-Doherty Earth Observatory and a Center for Climate and Life Fellow. Polissar uses molecular fossils—the remnants of plants and animals preserved in ocean, lake, and terrestrial sediments—to identify these organisms, understand what past landscapes and ecosystems looked like, and examine how climate shapes Earth's ecosystems.

New assay may help predict which pancreatic lesions may become cancerous

(Elsevier) A report in The Journal of Molecular Diagnostics, describes a new simple molecular test to detect chromosomal abnormalities -- biomarkers known as telomere fusions -- in pancreatic tumor specimens and pancreatic cyst fluids. This assay may help predict the presence of high-grade or invasive pancreatic cancers requiring surgical intervention.

The Structure of Cool

A team of researchers from The Scripps Research Institute (TSRI) and Duke University has made the first determination of the atomic structure of Transient Receptor Potential Melastatin 8 (TRPM8), a molecular sensor in nerve ends that detects cold temperatures as well as menthol and other chemicals that induce cold sensations.

Researchers discover the unexpected atomic structure of cold and menthol sensor TRPM8

A team of researchers from The Scripps Research Institute (TSRI) and Duke University has made the first determination of the atomic structure of Transient Receptor Potential Melastatin 8 (TRPM8), a molecular sensor in nerve ends that detects cold temperatures as well as menthol and other chemicals that induce cold sensations.

A spring-loaded sensor for cholesterol in cells

(American Society for Biochemistry and Molecular Biology) New research from the University of New South Wales in Sydney, Australia, to be published in the Journal of Biological Chemistry on Dec. 8, explains how an enzyme acts as a kind of thermostat that responds to and adjusts levels of cholesterol in the cell. Show More Summary

Mechanism identified behind enzyme involved in liver and other human cancers

(Uppsala University) To understand what has gone wrong when cancer occurs and to create new possibilities for treatment, it is important to understand the molecular mechanisms behind what is happening at the cellular level. New research,...Show More Summary

CMU receives $7.5m in federal BRAIN initiative funding

(Carnegie Mellon University) Researchers from Carnegie Mellon University's Departments of Biological Sciences and Chemistry, Molecular Biosensor and Imaging Center (MBIC) and Pittsburgh Supercomputing Center (PSC) have received close...Show More Summary

DNA damage repair—molecular insights

The first line of defense against skin cancer is the ability to repair DNA damage caused by UV light. The XPA protein plays an important role in the repair of certain DNA damage, and mutations in this protein have been implicated in xeroderma pigmentosum (XP) disorders, characterized by increased UV sensitivity and risk for skin cancer.

The molecular structure of a forest aroma deconstructed

(American Institute of Physics) The fresh, unmistakable scent of a pine forest comes from a medley of chemicals produced by its trees. Researchers have now accurately determined the chemical structure of one compound in its gas phase, a molecule called alpha-pinene. Show More Summary

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