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New machine learning system can automatically identify shapes of red blood cells

Using a computational approach known as deep learning, scientists have developed a new system to classify the shapes of red blood cells in a patient's blood. The findings, published in PLOS Computational Biology, could potentially help doctors monitor people with sickle cell disease.

The sea cucumber genome points to genes for tissue regeneration

A new high-definition genome sequence of the sea cucumber provides molecular insights into its ability to regenerate, according to a new study publishing 12 October in the open access journal PLOS Biology by Xiaojun Zhang, Lina Sun, Hongsheng Yang and Jianhai Xiang, of the Institute of Oceanology, Chinese Academy of Sciences, and colleagues. Show More Summary

Modeling Antibiotic Treatment in Hospitals, Inferring Synaptic Plasticity from Spiking, and Synthesizing Developmental Trajectories

Check out our highlights from the PLOS Computational Biology September issue:   Modeling antibiotic treatment in hospitals: A systematic approach shows benefits of combination therapy over cycling, mixing, and mono-drug therapies   For life-threatening infections,

Chicken embryo development data obtained in FANTOM project

(Kazan Federal University) The work is a part of FANTOM and was funded by a Russian-Japanese grant provided by the Russian Science Foundation. The results were published in PLOS Biology. The third institution involved was Kumamoto University.

Researchers obtain chicken embryo development data

KFU Extreme Biology Lab and RIKEN have uncovered new facts about chicken embryo growth, which may lead to similar discoveries about humans. The work is published in PLOS Biology.

A neuron’s eye view, recovering from intestinal cleanout, and models of cancer cell line metabolism

Check out our highlights from the PLOS Computational Biology August issue:   A systems approach reveals distinct metabolic strategies among the NCI-60 cancer cell lines Altered metabolism is characteristic of many human diseases, including cancer,

Mapping high-throughput data onto networks, modelling bacteria in 3D Colonies, and developing algorithms for Molecular Dynamics

Check out our highlights from the PLOS Computational Biology July issue:   PCSF: An R-package for network-based interpretation of high-throughput data With recent technological developments a vast amount of high-throughput data has been profiled in

Firing of neurons changes the cells that insulate them

(PLOS) Through their pattern of firing, neurons influence the behavior of the cells that upon maturation will provide insulation of neuronal axons, according to a new study publishing Aug. 22 in the open-access journal PLOS Biology by Balint Nagy, Maria Kukley and colleagues at the University of Tübingen, Germany. Show More Summary

New method identifies brain regions most likely to cause epilepsy seizures

(PLOS) Scientists have developed a new way to detect which areas of the brain contribute most greatly to epilepsy seizures, according to a PLOS Computational Biology study. The strategy, devised by Marinho Lopes of the University of Exeter and colleagues, could help surgeons select specific brain areas for removal to stop seizures.

Nominations open for the PLOS Computational Biology Research Prize!

Have you read a 2016 PLOS Computational Biology Research Article that stood out for you in terms scientific excellence or impact on your field? Maybe you edited or reviewed a manuscript that caught your attention? If so,

Even bacteria have baggage—and understanding that is key to fighting superbugs

New research points to treatment strategies for multi-drug antibiotic resistance using currently available drugs. The study, publishing August 8 in the open access journal PLOS Biology by Phillip Yen and Jason Papin at the University...Show More Summary

Brain Network Eigenmodes in Health and Disease, Olfactory Learning Without Mushroom Bodies, and Assessing Overlap of Genomic Features: the PLOS Comp Biol June Issue

Check out our highlights from the PLOS Computational Biology June issue:   Brain Network Eigenmodes Provide a Robust and Compact Representation of the Structural Connectome in Health and Disease While the structural connectome of th...

ISMB/ECCB 2017 – Visit PLOS at Booth 16!

Heading to Prague for ISMB/ECCB 2017? Swing by Booth 16 and say hello to PLOS! PLOS Computational Biology Publications Manager Gary Beardmore will be manning the booth, alongside Catherine Nancarrow, Senior Managing Editor, and Beth

Immune system cell clones created before birth may last for decades

(PLOS) Key immune system cells produced before birth may survive well into adulthood, according to new research published in PLOS Computational Biology.

Bad Identifiers are the Potholes of the Information Superhighway: Take-Home Lessons for Researchers

  By Julie McMurry, Lilly Winfree, Melissa Haendel   This is a guest post by three of the authors of a recent PLOS Biology article, discussed here. All three authors are at the Department of

A newly identified complex of Tau and RNA suggests a path to aggregation

(PLOS) The hallmark of many neurodegenerative diseases is the formation of protein aggregates, yet how and why these aggregates form remains a mystery. In a study publishing July 6 in the open-access journal PLOS Biology by the laboratories of Songi Han and Kenneth S. Show More Summary

Cancer researchers overestimate reproducibility of preclinical studies

(PLOS) Cancer scientists overestimate the extent to which high-profile preclinical studies can be successfully replicated, new research publishing June 29 in the open access journal PLOS Biology by Jonathan Kimmelman and colleagues from McGill University suggests.

Training changes the way the brain pays attention

(PLOS) Behavioral training changes the way attention facilitates information processing in the human brain, a study publishing on June 27 in the open access journal PLOS Biology led by Sirawaj Itthipuripat, at University of California San Diego, has found.

Simulated honeybees can use simple brain circuits for complex learning

Honeybees may not need key brain structures known as mushroom bodies in order to learn complex associations between odors and rewards, according to new research published in PLOS Computational Biology.

New brain network model could explain differences in brain injuries

(PLOS) Considering the brain's network of activity, rather than just individual regions, could help us understand why some brain injuries are much worse than others, according to a study published PLOS Computational Biology by Maxwell B. Wang, Julia Owen, and Pratik Mukherjee from University of California, San Francisco, and Ashish Raj from Weill Cornell Medicine.

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