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Fighting malaria through mathematical analysis of parasite's metabolism

(PLOS) A new mathematical model, based on the deadliest malaria parasite, Plasmodium falciparum, could help develop antimalarials by identifying key metabolic targets, according to a study published in PLOS Computational Biology by Vassily Hatzimanikatis at École Polytechnique Fédérale de Lausanne (EPFL), Switzerland, and colleagues.

Education in Computational Biology Today and Tomorrow

0000-0002-8715-2896 An archived “Perspective on science education” from the PLOS Computational Biology journal editors, of possible interest to readers of this blog. –PLOSBLOGS   Citation: Fox JA, Ouellette BFF (2013) Education in Computational Biology Today

New analysis method of metabolites accurately predicts whether a child has autism

(PLOS) Scientists have developed a new, highly accurate method that analyzes metabolic biomarkers to assess whether a child is on the autism spectrum, according to a study published in PLOS Computational Biology.

How big brains evolved could be revealed by new mathematical model

(PLOS) A new mathematical model could help clarify what drove the evolution of large brains in humans and other animals, according to a study published in PLOS Computational Biology.

A Novel Prostate Cancer Risk Variant in African Americans, Dynamics of the Human Gut Microbiome, and Geno-Pheno Maps for Digital Organisms: the PLOS Comp Biol February Issue

Check out our highlights from the PLOS Computational Biology February issue:   ALKBH7 variant related to prostate cancer exhibits altered substrate binding The search for prostate cancer biomarkers has received increased attention and several DNA

Cause of killer cardiac disease identified by new method

(PLOS) A team of researchers have invented a new method to identify the origin of irregular electrical 'storm waves' in the heart. This new research, published in PLOS Computational Biology, could have major implications for the future treatment of a killer cardiac disease.

Genome editing: Pressing the 'delete' button on DNA

Until recently, genomics was a "read-only" science, but scientists have developed a tool for quick and easy deletion of DNA in living cells. This software, published in PLOS Computational Biology, will boost efforts to understand the vast regions of non-coding DNA, or "Dark Matter", in our DNA and may lead to discovery of new disease-causing genes and potential new drugs.

Novel mutation may be linked to prostate cancer in African-American men

(PLOS) Researchers have identified a novel mutation that may be associated with prostate cancer in African-American men, according to a new study published in PLOS Computational Biology. Scientists have long known that a huge variety of DNA mutations can lead to cancer. Show More Summary

Better method developed for predicting onset of flu epidemics

A new study published in PLoS Computational Biology has developed a new method for better identifying and predicting the onset of a flu epidemic. Through the analysis of data collected from the European Centre for Disease Control, combined...Show More Summary

Toxic liver effects of fifteen drugs predicted using computational approach

(PLOS) A team of researchers has used a computational modeling approach to analyze and compare the toxic effects of fifteen different drugs on the liver, according to a study in PLOS Computational Biology.

Totally Paralyzed Patients Use a Computer to Tell Doctors Their Thoughts, They Say They’re Happy

Four completely paralyzed patients were able to communicate with researchers thanks to a newly developed brain-computer interface, according to a study published Tuesday in PLOS Biology. With the device, the European researchers watched...Show More Summary

Growing tumors put the pressure on nutrient-supplying blood vessels

(PLOS) Mechanical pressure caused by cancer growth plays a key role in the development and distribution of blood vessels in tumors, according to a new University College London study published in PLOS Computational Biology.

Malaria elimination: Vaccines should be tested on larger groups of volunteers

(PLOS) To find an effective vaccine against malaria it is crucial to test candidate vaccines on larger groups of people than previously thought -- according to a new study published in PLOS Computational Biology. The researchers from...Show More Summary

Classic video game system used to improve understanding of the brain

(PLOS) The complexity of neural networks makes them difficult to analyze, but manmade computing systems should be simpler to understand. In a study published in PLOS Computational Biology, researchers applied widely used neuroscience...Show More Summary

Ebola Modeling, Microbial Community Cross-Feeding, and Detecting Concussion: the PLOS Comp Biol December 2016 Issue

Check out our highlights from the last PLOS Computational Biology issue of 2016:   Spatiotemporal Analysis of the 2014 West African Ebola Epidemic   Infectious disease modelling has become an established tool to inform decisions

Restoring Insulin Secretion: Is it Possible?

Can nonfunctioning beta cells be rejuvenated? Researchers from Florida State University think they can. In a paper published in PLOS Computational Biology, the researchers, led by Richard Bertram, postulate that it’s oscillating pulses of glucose that cause the oscillating pulses of insulin that are seen in healthy people. Show More Summary

Control of emerging Ebola infections could be aided by new monitoring method

(PLOS) New research on the 2014 Ebola epidemic tracks the rate at which infections move from one district to another and how often infections cross the borders between countries. This study, published in PLOS Computational Biology, could...Show More Summary

High-resolution brain imaging could improve detection of concussions

(PLOS) High-resolution brain scans analyzed by machine learning algorithms could determine whether a patient has a concussion, according to a new study published in PLOS Computational Biology.

Scientists create first viable mathematical model of a key anti-Salmonella defense system

Scientists have created the first validated mathematical model of an important cellular defense mechanism against the bacterium Salmonella, according to a new study in PLOS Computational Biology.

Missed connections: As people age, memory-related brain activity loses cohesion

(PLOS) Groups of brain regions that synchronize their activity during memory tasks become smaller and more numerous as people age, according to a study published in PLOS Computational Biology.

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