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Quantum Dots Light Up Tumors Brighter Than Ever Before

Scientists at the Sanford Burnham Prebys Medical Discovery Institute (SBP) in San Diego, California have devised a way to optically image tumors with unprecedented clarity using quantum dots. These nano structures are tiny particles, only a few nanometers wide, that generate light of a specific wavelength when they’re themselves stimulated by a light beam. On […]

Heart hormones protect against obesity and insulin resistance

(Sanford-Burnham Prebys Medical Discovery Institute) By fleshing out how one signaling receptor contributes to causing obesity through its activity in fatty tissue but not in muscle cells, SBP scientists have zeroed in on an important new avenue of exploration for combating metabolic disease. Show More Summary

Scientists develop novel 'dot' system to improve cancer detection

La Jolla, Calif., August 24, 2017 - Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) have developed a proof-of-concept nanosystem that dramatically improves the visualization of tumors. Published today in Nature Communications, the platform achieves a five-fold increase over existing tumor-specific optical imaging methods. Show More Summary

Scientists develop novel 'dot' system to improve cancer detection

(Sanford-Burnham Prebys Medical Discovery Institute) SBP researchers advance tumor-imaging nanosystem for enhanced diagnostic imaging.

Where do heart cells come from?

(Sanford-Burnham Prebys Medical Discovery Institute) Researchers from Sanford Burnham Prebys Medical Discovery Institute, the Cardiovascular Institute at Stanford University and other institutions were surprised to discover that the four genes in the Id family play a crucial role in heart development, telling undifferentiated stem cells to form heart tubes and eventually muscle.

Sanford Burnham Prebys and Mayo Clinic Collaborators Awarded Multi-Year NIH Grant

A team of researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) at Lake Nona, Fla. and Mayo Clinic in Rochester, Minn. have been awarded a three-year National Institutes of Health(NIH) grant which aims to identify molecules that could become new medicines to inhibit myocardial fibrosis. Show More Summary

Sanford Burnham Prebys and Mayo Clinic collaborators awarded multi-year NIH grant

(Sanford-Burnham Prebys Medical Discovery Institute) A team of researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) at Lake Nona, Fla. and Mayo Clinic in Rochester, Minnesota have been awarded a three-year National...Show More Summary

Drug short-circuits cancer signaling

(Sanford-Burnham Prebys Medical Discovery Institute) A new drug zeroes in on mutated nuclear receptors found in cancer and leaves normal proteins alone.

Steps toward a promising therapy for a rare bone disease

(Sanford-Burnham Prebys Medical Discovery Institute) Study examines the therapeutic potential of a small molecule to treat hereditary bony tumors.

Comparing algorithms that search for cancer mutations

(Sanford-Burnham Prebys Medical Discovery Institute) Scientists team up to evaluate the tools used to probe the cancer genome.

Scientists take a deeper dive into cellular trash

(Sanford-Burnham Prebys Medical Discovery Institute) SBP researchers provide new insights on the connection between autophagy and lifespan.

Researchers provide new insights on the connection between autophagy and lifespan

Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) have undertaken the first ever comprehensive analysis of autophagy in a living animal during aging. "Autophagy," which means "self-eating" based on its Greek roots,...Show More Summary

Fruit Flies Journey to International Space Station to Study Effects of Zero Gravity on the Heart

Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) today announced six boxes of fruit flies (Drosophila melanogaster) will travel to the International Space Station (ISS) to study the impact of weightlessness on the heart. Show More Summary

New Zika virus inhibitor identified

(Sanford-Burnham Prebys Medical Discovery Institute) Compound could serve as basis for drugs to prevent neurological complications of Zika.

Underlying molecular mechanism of bipolar disorder revealed

(Sanford-Burnham Prebys Medical Discovery Institute) Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP), with major participation from Yokohama School of Medicine, Harvard Medical School, and UC San Diego, have identified the molecular mechanism behind lithium's effectiveness in treating bipolar disorder patients. Show More Summary

Mysterious molecule's function in skin cancer identified

(Sanford-Burnham Prebys Medical Discovery Institute) SBP researcher Ranjan Perera uncovered the M.O. of a mysterious molecule called SPRIGHTLY that acts as a hub for cancer-related genes in the nucleus. The study identified 'major' RNA binding partners -- genes already implicated in a variety of cancers. Show More Summary

New insights on triggering muscle formation

(Sanford-Burnham Prebys Medical Discovery Institute) A team of scientists led by Lorenzo Puri, M.D., Ph.D., has identified a previously unrecognized step in stem cell-mediated muscle regeneration. The study, published in Genes and Development,...Show More Summary

Research Could Lead to Better Vaccines and New Antivirals

Scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified a new regulator of the innate immune response--the immediate, natural immune response to foreign invaders. The study, published recently in Nature...Show More Summary

Research could lead to better vaccines and new antivirals

(Sanford-Burnham Prebys Medical Discovery Institute) Scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified a new regulator of the innate immune response -- the immediate, natural immune response to foreign invaders. Show More Summary

What doesn't kill you makes you stronger

(Sanford-Burnham Prebys Medical Discovery Institute) New research from Sanford Burnham Prebys Medical Discovery Institute (SBP) could help explain why brief bodily stresses--going to the sauna or for a run, for example--are good for health and longevity. Show More Summary

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