Dementia is characterized by a progressive and debilitating decline in cognition, function and behavior. Its numbers are staggering: according to the World Health Organization, the total number of people with dementia worldwide in 2010 was estimated at 35.6 million and predicted to nearly double every 20 years, to 65.7 million in 2030 and 115.4 million […]
The amyloid cascade hypothesis of Alzheimer's disease (AD) posits that sticky aggregations or plaques of amyloid-beta peptides accumulate over time in the brain, triggering a series of events that ultimately result in the full-blown neurodegenerative disorder. Show More Summary
UC San Diego School of Medicine researchers report that the amyloid cascade hypothesis, long believed to describe the pathology of Alzheimer's disease, is not a fixed and invariable sequence of events. Rather, early indicators or biomarkers of the neurodegenerative condition vary by individual, making preclinical diagnoses more challenging.
Arguably the most urgent and seemingly intractable of all the healthcare issues facing us today is Alzheimer’s disease (AD), which is marked by progressive, inexorable loss of intellectual and social skills and ultimately, death. AsShow More Summary
A brain protein believed to be a key component in the progress of dementia can cause memory loss in healthy brains even before physical signs of degeneration appear, according to new research.
Making a connection is essential for the well being of people living with Alzheimer’s. There are four special activities that can typically reach and engage people at any point in the disease’s progression, even with those in the later stages who may no longer talk or smile, let alone recognize love ones. Show More Summary
More than 5 million Americans are living with Alzheimer's with no cure or treatment to reverse the progression. So medical professionals are constantly seeking ways to improve quality of life for their patients. One new method is a pilot...Show More Summary
The slow progress towards viable therapies for Alzheimer's disease based on clearance of ?-amyloid, such as via immunotherapy, has led to a broadening of approaches. Many research groups are looking at other theories on causative mechanisms...Show More Summary
From MedPage Today: CSF Biomarker May Predict Early AD Progression. Cerebrospinal fluid (CSF) levels of a certain brain protein may be a helpful predictor of progression to Alzheimer’s disease. Diabetes More Likely in Children in Stressful Homes. Show More Summary
A drug discovery could hold promise in the fight against the devastating effects of Alzheimer's Disease. Scientists, using a animal model, have completed research to suggest that the drug Edaravone could alleviate the progressive cognitive deficits of Alzheimer's Disease, a major social and economic burden worldwide.
Alzheimer's Reading Room By examining more than 3,600 postmortem brains, researchers at the Mayo Clinic found that the progression of dysfunctional tau protein drives the cognitive decline and memory loss seen in Alzheimer’s disease....Show More Summary
By examining more than 3,600 postmortem brains, researchers have found that the progression of dysfunctional tau protein drives the cognitive decline and memory loss seen in Alzheimer’s disease.
The struggle to show meaningful progress in treatment of Alzheimer's disease via clearance of amyloid has fueled significant investment into alternative hypotheses regarding the disease process. The biochemistry of Alzheimer's - andShow More Summary
By examining more than 3,600 postmortem brains, researchers at Mayo Clinic's campuses in Jacksonville, Florida, and Rochester, Minnesota, have found that the progression of dysfunctional tau protein drives the cognitive decline and memory loss seen in Alzheimer's disease.
A promising new natural treatment for Alzheimer's disease is moving toward clinical trials. This will be a major step forward as there is nothing on the market that slows the progression of Alzheimer's; natural products chemist has patented a botanical compound, withanamides.
Researchers have identified a promising new target in the battle against certain neurological diseases. A protein known as TREM2 has been proven effective in clearing away unwanted debris in the brain, the unchecked buildup of which can lead to both Alzheimer's disease and multiple sclerosis (MS)... Show More Summary
Highlighting a potential target in the treatment of multiple sclerosis (MS) and Alzheimer's disease, new research suggests that triggering a protein found on the surface of brain cells may help slow the progression of these and other neurological diseases.
Can the Alzheimer's caregiver make a difference in the progression of Alzheimer's disease? Is it possible that Alzheimer's caregiver love can be as effective, or more effective, than the drugs that are currently available for the treatment...Show More Summary
Our susceptibility to disease depends both on the genes that we inherit from our parents and on our lifetime experiences. These two components -- nature and nurture -- seem to affect very different processes in the context of Alzheimer's disease. A new study of epigenomic modifications reveals the immune basis of Alzheimer's disease.
A molecular chaperone has been found to inhibit a key stage in the development of Alzheimer’s disease and break the toxic chain reaction that leads to the death of brain cells. By Alzheimer's Reading Room A molecule that can block the...Show More Summary