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Research suggests new pathways for hyperaldosteronism

(Sanford-Burnham Prebys Medical Discovery Institute) Researchers have identified a mechanism that explains the development of hyperaldosteronism, a condition in which the adrenal glands produce too much aldosterone. The findings, published in JCI Insight, offer a path for drug discovery to treat the condition.

D'Angelo receives American Cancer Society Research Scholar grant

(Sanford-Burnham Prebys Medical Discovery Institute) Maximiliano D'Angelo, Ph.D., an assistant professor at Sanford Burnham Prebys Medical Discovery Institute (SBP), has received a four-year, $792,000 Research Scholar Grant from the American Cancer Society.

Scientists find key to regenerating blood vessels

(Sanford-Burnham Prebys Medical Discovery Institute) Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified a signaling pathway that is essential for angiogenesis, the growth of new blood vessels from pre-existing vessels. Show More Summary

Preclinical study demonstrates promising treatment for rare bone disease

(Sanford-Burnham Prebys Medical Discovery Institute) Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) have led a preclinical study demonstrating that the drug palovarotene suppresses the formation of bony tumors (osteochondromas) in models of multiple hereditary exostoses (MHE). Show More Summary

Anti-malaria drug shows promise as Zika virus treatment

(Sanford-Burnham Prebys Medical Discovery Institute) California researchers have discovered that a medication used to prevent and treat malaria may also be effective for Zika virus. The drug, called chloroquine, has a long history of safe use during pregnancy, and is relatively inexpensive. The research was published today in Scientific Reports.

New player in Alzheimer's disease pathogenesis identified

(Sanford-Burnham Prebys Medical Discovery Institute) Scientists have shown that a protein called membralin is critical for keeping Alzheimer's disease pathology in check. The study, published in Nature Communications, shows that membralin...Show More Summary

Biomarker may predict early Alzheimer's disease

(Sanford-Burnham Prebys Medical Discovery Institute) Researchers at SBP have identified a peptide that could lead to the early detection of Alzheimer's disease (AD). The discovery, published in Nature Communications, may also provide a means of homing drugs to diseased areas of the brain to treat AD, Parkinson's disease, as well as glioblastoma, brain injuries and stroke.

New clues to treat Alagille Syndrome from zebrafish

(Sanford-Burnham Prebys Medical Discovery Institute) A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) identifies potential new therapeutic avenues for patients with Alagille syndrome, a rare genetic disorder caused by mutations primarily in the JAGGED1 gene.

New insights on the addictions of tumors

(Sanford-Burnham Prebys Medical Discovery Institute) Stromal tissue may provide novel targets to disrupt tumor supply lines.

Alternative splicing, an important mechanism for cancer

(Sanford-Burnham Prebys Medical Discovery Institute) Scientists discover several alterations in this cellular process with implications in cancer by analyzing samples from more than 4,000 patients.

SBP scientist receives $10.8 million grant to advance potential drug for substance abuse

(Sanford-Burnham Prebys Medical Discovery Institute) A new class of drug may help treat cocaine and nicotine addiction.

Heart hormones protect against obesity and insulin resistance

(Sanford-Burnham Prebys Medical Discovery Institute) By fleshing out how one signaling receptor contributes to causing obesity through its activity in fatty tissue but not in muscle cells, SBP scientists have zeroed in on an important new avenue of exploration for combating metabolic disease. Show More Summary

Scientists develop novel 'dot' system to improve cancer detection

(Sanford-Burnham Prebys Medical Discovery Institute) SBP researchers advance tumor-imaging nanosystem for enhanced diagnostic imaging.

Where do heart cells come from?

(Sanford-Burnham Prebys Medical Discovery Institute) Researchers from Sanford Burnham Prebys Medical Discovery Institute, the Cardiovascular Institute at Stanford University and other institutions were surprised to discover that the four genes in the Id family play a crucial role in heart development, telling undifferentiated stem cells to form heart tubes and eventually muscle.

Sanford Burnham Prebys and Mayo Clinic collaborators awarded multi-year NIH grant

(Sanford-Burnham Prebys Medical Discovery Institute) A team of researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) at Lake Nona, Fla. and Mayo Clinic in Rochester, Minnesota have been awarded a three-year National...Show More Summary

Drug short-circuits cancer signaling

(Sanford-Burnham Prebys Medical Discovery Institute) A new drug zeroes in on mutated nuclear receptors found in cancer and leaves normal proteins alone.

Steps toward a promising therapy for a rare bone disease

(Sanford-Burnham Prebys Medical Discovery Institute) Study examines the therapeutic potential of a small molecule to treat hereditary bony tumors.

Comparing algorithms that search for cancer mutations

(Sanford-Burnham Prebys Medical Discovery Institute) Scientists team up to evaluate the tools used to probe the cancer genome.

Scientists take a deeper dive into cellular trash

(Sanford-Burnham Prebys Medical Discovery Institute) SBP researchers provide new insights on the connection between autophagy and lifespan.

New Zika virus inhibitor identified

(Sanford-Burnham Prebys Medical Discovery Institute) Compound could serve as basis for drugs to prevent neurological complications of Zika.

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