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3-D atomic structure of TRPML1 ion channel published

UT Southwestern Medical Center researchers today published a 3-D atomic structure of the ion channel found in mammals that is implicated in a rare, inherited neurodegenerative disease in humans. The work marks the first such structure determined using the university's $17 million cryo-electron microscopy (cryo-EM) facility that opened last year.

First Atomic Structure From UTSW's Cryo-EM Facility

UT Southwestern Medical Center researchers today published a 3-D atomic structure of the ion channel found in mammals that is implicated in a rare, inherited neurodegenerative disease in humans.

CRI study challenges long-standing concept in cancer metabolism

(UT Southwestern Medical Center) Scientists at the Children's Medical Center Research Institute at UT Southwestern (CRI) have discovered that lactate provides a fuel for growing tumors, challenging a nearly century-old observation known as the Warburg effect.

Good-guy bacteria may help cancer immunotherapies do their job

(UT Southwestern Medical Center) Individuals with certain types of bacteria in their gut may be more likely to respond well to cancer immunotherapy, researchers at the Harold C. Simmons Comprehensive Cancer Center found in a study of patients with metastatic melanoma.

Genetic targets to chemo-resistant breast cancer identified

(UT Southwestern Medical Center) Research led by Dr. Carlos Arteaga, Director of the Harold C. Simmons Comprehensive Cancer Center, has identified potential targets for treatment of triple negative breast cancer, the most aggressive form of breast cancer.

South Asians with family history of heart disease at greater risk

(UT Southwestern Medical Center) New research by UT Southwestern cardiologists shows that people of South Asian descent with a family history of coronary heart disease are significantly more likely to have high levels of calcium buildup in their arteries - an indicator of higher risk for heart attacks.

Texas Health, UT Southwestern kick off new health care campus in Collin County

Texas Health Resources and UT Southwestern Medical Center joined today with Frisco city leaders to kick off a construction project that will bring an acute care hospital and multispecialty clinic complex to this rapidly growing part of Collin County.

DNA sensor plays critical role in cancer immunotherapy via response to unexpected DNA form

(UT Southwestern Medical Center) UT Southwestern Medical Center researchers report for the first time that tumors stressed by cancer immunotherapy release their mitochondrial DNA into nearby immune cells, triggering a host alert sys...

DNA Sensor Plays Critical Role in Cancer Immunotherapy via Robust Response to Unexpected Form of DNA

UT Southwestern Medical Center researchers report for the first time that tumors stressed by cancer immunotherapy release their mitochondrial DNA into nearby immune cells, triggering a host alert system.

CRI scientists characterize regulatory DNA sequences responsible for human diseases

(UT Southwestern Medical Center) Scientists from the Children's Medical Center Research Institute at UT Southwestern have developed an innovative system to identify and characterize the molecular components that control the activities of regulatory DNA sequences in the human genome.

Vitamin C regulates stem cell function, curbs leukemia development, scientists discover

Not much is known about stem cell metabolism, but a new study from the Children's Medical Center Research Institute at UT Southwestern has found that stem cells take up unusually high levels of vitamin C, which then regulates their function and suppresses the development of leukemia.

CRI scientists discover vitamin C regulates stem cell function, curbs leukemia development

(UT Southwestern Medical Center) Not much is known about stem cell metabolism, but a new study from the Children's Medical Center Research Institute at UT Southwestern has found that stem cells take up unusually high levels of vitamin C, which then regulates their function and suppresses the development of leukemia.

CRI Scientists Discover Vitamin C Regulates Stem Cell Function and Suppresses Leukemia Development

Not much is known about stem cell metabolism, but a new study from the Children's Medical Center Research Institute at UT Southwestern (CRI) has found that stem cells take up unusually high levels of vitamin C, which then regulates their function and suppresses the development of leukemia.

Eating habits affect skin's protection against sun

(UT Southwestern Medical Center) Sunbathers may want to avoid midnight snacks before catching some rays.

Clinical trial eligibility criteria a growing obstacle

(UT Southwestern Medical Center) Despite a decade-long call for simplification of clinical trials, the number of criteria excluding patients from participating in clinical trials for lung cancer research continues to rise.

UT Southwestern ranks No. 5 in the world in research that drives further innovation

UT Southwestern Medical Center ranks fifth in the world in the number of published research articles cited as significant sources in third-party patent applications. This new measurement is a way to evaluate an institution's impact and...Show More Summary

UT Southwestern ranked No. 1 hospital in Dallas-Ft. Worth by U.S. News & World Report

UT Southwestern Medical Center is the No. 1-ranked hospital in Dallas-Fort Worth, second in Texas, and nationally ranked among the top 50 programs in six clinical specialty areas, according to U.S. News & World Report's annual Best Hospitals listings released today.

Magnetic Fields to Destroy Bacteria on Artificial Joints

2 months agoIndustries / Medical : medGadget

Scientists at UT Southwestern Medical Center have developed a new technique using high-frequency alternating magnetic fields to heat artificial joints in the body and destroy bacterial films on their surfaces. Bacterial infections on artificial joints used in knee and hip replacements are a common and serious complication. The bacteria tend to form slimy films on the […]

Black Men Have Lowest Survival Rates Among Patients with Anal Cancer

As published in JNCCN - Journal of the National Comprehensive Cancer Network, researchers at UT Southwestern Medical Center found significant racial and gender-based disparities in outcomes among patients with locoregional anal canc...

Magnetic fields turn up the heat on bacterial biofilms

(UT Southwestern Medical Center) A short exposure to an alternating magnetic field might someday replace multiple surgeries and weeks of IV antibiotics as treatment for stubborn infections on artificial joints, new research suggests...

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