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CLOCK gene may hold answers to human brain evolution

(UT Southwestern Medical Center) A gene controlling our biological clocks plays a vital role in regulating human-specific genes important to brain evolution. The findings from the O'Donnell Brain Institute open new paths of research into how CLOCK proteins produced by the CLOCK gene affect brain function and the processes by which neurons find their proper place in the brain.

UTSW researchers identify possible new way to treat parasitic infections

(UT Southwestern Medical Center) UT Southwestern Medical Center researchers have identified a chemical that suppresses the lethal form of a parasitic infection caused by roundworms that affects up to 100 million people and usually causes only mild symptoms.

Researchers Devise Improved Gene-Editing Process for Duchenne Muscular Dystrophy

Regenerative medicine researchers at UT Southwestern Medical Center developed an improved and simplified gene-editing technique using CRISPR/Cas9 tools to correct a common mutation that causes Duchenne muscular dystrophy.

UTSW Scientists Take Early Step to Personalized Breast Cancer Care

UT Southwestern Medical Center researchers have developed a method to map protein changes that occur in different subtypes of breast cancer cells in response to DNA damage from a new class of chemotherapy drugs.

Critical link between obesity and diabetes has been identified

(UT Southwestern Medical Center) UT Southwestern researchers have identified a major mechanism by which obesity causes type 2 diabetes, which is a common complication of being overweight that afflicts more than 30 million Americans and over 400 million people worldwide.

New studies show brain impact of youth football

CHICAGO - School-age football players with a history of concussion and high impact exposure undergo brain changes after one season of play, according to two new studies conducted at UT Southwestern Medical Center in Dallas and Wake Forest University in Winston-Salem and presented today at the annual meeting of the Radiological Society of North America (RSNA).

Deletion of a stem cell factor promotes TBI recovery in mice

(UT Southwestern Medical Center) Researchers found that conditional deletion of Sox2 -- the gene encoding the SOX2 stem cell transcription factor -- and the associated dampening of astrocyte reactivity appear to promote functional recovery, including behavioral recovery, after traumatic brain injury, said Dr. Zhang, a W.W. Caruth, Jr. Scholar in Biomedical Research.

Uninsured Heart Attack, Stroke Patients Face 'Catastrophic' Costs

Heart attack and stroke patients without medical insurance face "devastating" health care costs that can bankrupt them, research from UT Southwestern and other centers shows.

Hong Named THR Clinical Scholar

Dr. Arthur Hong, Assistant Professor of Internal Medicine and Clinical Sciences at UT Southwestern Medical Center, has been selected as recipient of the Texas Health Resources Clinical Scholar Award for his research into how to improve the cost, quality, and delivery of health care.

Depressed with a chronic disease? Consider alternative therapies

(UT Southwestern Medical Center) Scientists are finding more evidence that commonly prescribed antidepressants aren't effective in people battling both depression and a chronic medical disease, raising a critical question of whether doctors should enact widespread changes in how they treat millions of depressed Americans.

3-D atomic structure of TRPML1 ion channel published

UT Southwestern Medical Center researchers today published a 3-D atomic structure of the ion channel found in mammals that is implicated in a rare, inherited neurodegenerative disease in humans. The work marks the first such structure determined using the university's $17 million cryo-electron microscopy (cryo-EM) facility that opened last year.

First Atomic Structure From UTSW's Cryo-EM Facility

UT Southwestern Medical Center researchers today published a 3-D atomic structure of the ion channel found in mammals that is implicated in a rare, inherited neurodegenerative disease in humans.

CRI study challenges long-standing concept in cancer metabolism

(UT Southwestern Medical Center) Scientists at the Children's Medical Center Research Institute at UT Southwestern (CRI) have discovered that lactate provides a fuel for growing tumors, challenging a nearly century-old observation known as the Warburg effect.

Good-guy bacteria may help cancer immunotherapies do their job

(UT Southwestern Medical Center) Individuals with certain types of bacteria in their gut may be more likely to respond well to cancer immunotherapy, researchers at the Harold C. Simmons Comprehensive Cancer Center found in a study of patients with metastatic melanoma.

Genetic targets to chemo-resistant breast cancer identified

(UT Southwestern Medical Center) Research led by Dr. Carlos Arteaga, Director of the Harold C. Simmons Comprehensive Cancer Center, has identified potential targets for treatment of triple negative breast cancer, the most aggressive form of breast cancer.

South Asians with family history of heart disease at greater risk

(UT Southwestern Medical Center) New research by UT Southwestern cardiologists shows that people of South Asian descent with a family history of coronary heart disease are significantly more likely to have high levels of calcium buildup in their arteries - an indicator of higher risk for heart attacks.

Texas Health, UT Southwestern kick off new health care campus in Collin County

Texas Health Resources and UT Southwestern Medical Center joined today with Frisco city leaders to kick off a construction project that will bring an acute care hospital and multispecialty clinic complex to this rapidly growing part of Collin County.

DNA sensor plays critical role in cancer immunotherapy via response to unexpected DNA form

(UT Southwestern Medical Center) UT Southwestern Medical Center researchers report for the first time that tumors stressed by cancer immunotherapy release their mitochondrial DNA into nearby immune cells, triggering a host alert sys...

DNA Sensor Plays Critical Role in Cancer Immunotherapy via Robust Response to Unexpected Form of DNA

UT Southwestern Medical Center researchers report for the first time that tumors stressed by cancer immunotherapy release their mitochondrial DNA into nearby immune cells, triggering a host alert system.

CRI scientists characterize regulatory DNA sequences responsible for human diseases

(UT Southwestern Medical Center) Scientists from the Children's Medical Center Research Institute at UT Southwestern have developed an innovative system to identify and characterize the molecular components that control the activities of regulatory DNA sequences in the human genome.

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