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Typhoid outbreak: Genetic cause of extensive drug-resistance found

(Wellcome Trust Sanger Institute) The genetic cause behind a strain of typhoid's resistance to five classes of antibiotics has been uncovered by scientists at the Wellcome Sanger Institute and their collaborators. There is currently a major outbreak of typhoid fever in Pakistan. Show More Summary

25 species revealed for 25 Genomes Project

To commemorate the Wellcome Trust Sanger Institute turning 25 in 2018, the Institute and its collaborators are sequencing 25 new genomes of species in the UK. The final five species have now been chosen by thousands of school children and members of the public around the globe, who participated in the 25 Genomes Project online vote.

25 species revealed for 25 Genomes Project

(Wellcome Trust Sanger Institute) To commemorate the Wellcome Trust Sanger Institute turning 25 in 2018, the Institute and its collaborators are sequencing 25 new genomes of species in the UK. The final five species have now been chosen by thousands of school children and members of the public around the globe, who participated in the 25 Genomes Project online vote.

Unforeseen new drug target discovered for acute myeloid leukemia

(Wellcome Trust Sanger Institute) A study reported in Nature has found an unexpected new drug target for acute myeloid leukemia that could open new avenues to develop effective treatments against this potentially lethal disease. Researchers...Show More Summary

'Mini liver tumors' created in a dish for the first time

(Wellcome Trust) Scientists have created mini biological models of human primary liver cancers, known as organoids, in the lab for the first time. In a paper published today in Nature Medicine, the tiny laboratory models of tumors were used to identify a new drug that could potentially treat certain types of liver cancer.

Cholera: The link between the world's major outbreaks leads to better control strategies

(Institut Pasteur) Researchers at the Institut Pasteur and the Wellcome Trust Sanger Institute, in collaboration with international institutions, recently published two studies tracing the history of cholera outbreaks from the last 60 years. Show More Summary

Risk of cholera epidemics estimated with new rule-book

(Wellcome Trust Sanger Institute) Cholera has repeatedly traveled out of Asia to cause epidemics in Africa and Latin America, an international research team has found. Researchers at the Wellcome Trust Sanger Institute, Institut Pasteur...Show More Summary

25 new genomes to celebrate 25 years of the Sanger Institute

To commemorate the Wellcome Trust Sanger Institute turning 25 in 2018, the Institute and its collaborators are sequencing 25 new genomes. From the blackberry to the robin, bush cricket to brown trout, the 25 species all reside in the UK and represent the richness of species in this country. Show More Summary

25 new genomes to celebrate 25 years of the Sanger Institute

(Wellcome Trust Sanger Institute) To commemorate the Wellcome Trust Sanger Institute turning 25 in 2018, the Institute and its collaborators are sequencing 25 new genomes. From the blackberry to the robin, bush cricket to brown trout, the 25 species all reside in the UK and represent the richness of species in this country. Show More Summary

Five new malaria targets that could lead to an effective vaccine

In the largest study of its kind, five new malaria vaccine targets have been discovered by scientists at the Wellcome Trust Sanger Institute and their collaborators. Researchers studied the malaria parasite at its most vulnerable stage - when invading human red blood cells - and identified five targets that lead to a reduction in the parasite's ability to enter red blood cells.

One to 10 mutations are needed to drive cancer, scientists find

(Wellcome Trust Sanger Institute) For the first time, scientists have provided unbiased estimates of the number of mutations needed for cancers to develop, in a study of more than 7,500 tumors across 29 cancer types. Researchers from...Show More Summary

Yeast spotlights genetic variation's link to drug resistance

Researchers have shown that genetic diversity plays a key role in enabling drug resistance to evolve. Scientists at the Wellcome Trust Sanger Institute and the Institute for Research on Cancer and Ageing of Nice in France, show that high genetic diversity can prime new mutations that cause drug resistance. Show More Summary

New drug hope for rare bone cancer patients

Patients with a rare bone cancer of the skull and spine - chordoma - could be helped by existing drugs, suggest scientists from the Wellcome Trust Sanger Institute, University College London Cancer Institute and the Royal National Orthopaedic Hospital NHS Trust. Show More Summary

New drug hope for rare bone cancer patients

(Wellcome Trust Sanger Institute) Patients with a rare bone cancer of the skull and spine -- chordoma -- could be helped by existing drugs, suggest scientists from the Wellcome Trust Sanger Institute, University College London Cancer Institute and the Royal National Orthopaedic Hospital NHS Trust. Show More Summary

New type of stem cell line produced offers expanded potential for research and treatments

Researchers at the Wellcome Trust Sanger Institute and their collaborators have created Expanded Potential Stem Cells (EPSCs) in mice, for the first time, that have a greater potential for development than current stem cell lines. These stem cells have the features of the very first cells in the developing embryo, and can develop into any type of cell.

Huge genetic diversity among Papuan New Guinean peoples revealed

The first large-scale genetic study of people in Papua New Guinea has shown that different groups within the country are genetically highly different from each other. Scientists at the Wellcome Trust Sanger Institute and their colleagues...Show More Summary

Immunotherapy treatment option for selected breast cancer patients, genetic study suggests

(Wellcome Trust Sanger Institute) Immunotherapy drugs could help some breast cancer patients based on the genetic changes in their tumors, researchers at the Wellcome Trust Sanger Institute and their collaborators find. Published today in Cancer Research, scientists identify particular genetic changes in a DNA repair mechanism in breast cancer. Show More Summary

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