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Online epidemic tracking tool embraces open data and collective intelligence

(Wellcome Trust Sanger Institute) Researchers from the Wellcome Trust Sanger Institute and Imperial College London have developed Microreact, a free, real-time epidemic visualization and tracking platform that has been used to monitor outbreaks of Ebola, Zika and antibiotic-resistant microbes. Show More Summary

Enhanced CRISPR lets scientists explore all steps of health and disease in every cell type

(Wellcome Trust Sanger Institute) Today, in the journal Development, scientists describe how a freely available single-step system works in every cell in the body and at every stage of development. This new approach will aid researchers in developmental biology, tissue regeneration and cancer.

Enhanced CRISPR lets scientists explore all steps of health and disease in every cell type

Wellcome Trust Sanger Institute and University of Cambridge researchers have created sOPTiKO, a more efficient and controllable CRISPR genome editing platform. Today, in the journal Development, they describe how the freely available single-step system works in every cell in the body and at every stage of development. Show More Summary

Smoking a pack a day for a year causes 150 mutations in lung cells

(Wellcome Trust Sanger Institute) Scientists have measured the catastrophic genetic damage caused by smoking in different organs of the body and identified several different mechanisms by which tobacco smoking causes mutations in DNA. Show More Summary

Center of gravity for African research funding shifts closer to Africa

(Wellcome Trust) The Wellcome Trust is shifting the center of gravity of its funding for African science from the UK to the continent itself by handing over two major research programs to the African Academy of Sciences' Alliance for Accelerating Excellence in Science in Africa (AAS-AESA).

Vulnerabilities of leukemia cells revealed using genome editing technique

(Wellcome Trust Sanger Institute) Researchers from the Wellcome Trust Sanger Institute and their collaborators have adapted a CRISPR gene editing technique and used it to find new therapeutic targets for acute myeloid leukemia (AML)....Show More Summary

International Human Cell Atlas Initiative

(Wellcome Trust Sanger Institute) The first project of its kind, as ambitious as the Human Genome Project, the Human Cell Atlas aims to chart the types and properties of all human cells, across all tissues and organs, to build a reference...Show More Summary

Health research: Africa–India health-science partnerships

3 months agoAcademics : Nature

Africa and India have common problems of communicable and non-communicable diseases, high maternal and child mortality, and weak health-delivery systems. Together with other funders, the Wellcome Trust is supporting capacity-building and innovation in health research in both regions, through the Alliance for Accelerating Excellence in

Study reveals how ionising radiation damages DNA and causes cancer

(Wellcome Trust Sanger Institute) For the first time, researchers from the Wellcome Trust Sanger Institute and their collaborators have been able to identify in human cancers two characteristic patterns of DNA damage caused by ionizing radiation. Show More Summary

Wellcome Trust: Report released on antibiotic resistance

3 months agoAcademics : Nature

The Wellcome Trust today releases a report to inform the United Nations General Assembly's High-level Meeting on Antimicrobial Resistance later this month (see www.wellcome.ac.uk/drugresistantinfections). The report distils the findings of an international summit of researchers, policymakers and multilateral institutions that met in London in

New study shows esophageal cancers driven by 'marginal gain' rather than speed

Wellcome Trust Sanger Institute scientists have shown that unexpectedly, oesophageal cancer cells do not divide faster than their normal neighbours. But unlike normal cells, the tumour cells produce slightly more dividing daughter cells...Show More Summary

The Joy of Pronking

Eadweard Muybridge's study of a deer in motion. (Photo: Wellcome Trust V0048764/CC BY 4.0) The other day, I was driving along a road in upstate New York when I saw a deer. This isn’t an unusual sight in itself, but this fawn, young enough...Show More Summary

New intellectual disability syndrome caused by genetic damage to single gene

Scientists at the Wellcome Trust Sanger Institute and Max Planck Institute for Psycholinguistics have found a gene responsible for an intellectual disability disorder and proven how it works. The research, published in the American Journal of Human Genetics, details the role of a gene called BCL11A in a new intellectual disability syndrome. read more

Why the new Wellcome Trust open review journal may be the science publishing future

John Bohannan in Science writes one of many stories about the Wellcome Trust establishing a new open access journal, in which peer review follows the posting of preprints: “U.K. research charity will self-publish results from its grantees”. Normally, peer review is anonymous and happens before publication of a paper. Show More Summary

Red hair gene variation drives up skin cancer mutations

For the first time, researchers at the Wellcome Trust Sanger Institute and University of Leeds have proved that gene variants associated with red hair, pale skin and freckles are linked to a higher number of genetic mutations in skin cancers. Show More Summary

Early screening spots emergency workers at greater risk of mental illness

Emergency services workers who are more likely to suffer episodes of mental ill health later in their careers can be spotted in the first week of training. That's the conclusion of a Wellcome Trust funded study carried out with trainee...Show More Summary

Sanger Institute: Landmark study shows AML is at least 11 different diseases

Scientists at the Wellcome Trust Sanger Institute and their international collaborators have shown that Acute Myeloid Leukaemia (AML) is not a single disorder, but at least 11 different diseases, and that genetic changes explain differences in survival among young AML patients. Show More Summary

New safety and efficacy evidence for mitochondrial donation revealed

A new IVF-based technique is likely to lead to normal pregnancies and reduce the risk that babies born will have mitochondrial disease, according to researchers at the Wellcome Trust Centre for Mitochondrial Disease at Newcastle University. Published...Show More Summary

How Wellcome and Gates charities profit from helping biotech

By Ben Hirschler LONDON (Reuters) - The Wellcome Trust medical charity is to profit from U.S. approval of a new diagnostic cancer test, the first commercial product funded by the organization since the sale of its pharmaceuticals business to Glaxo in 1995. Show More Summary

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