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'Mini liver tumors' created in a dish for the first time

(Wellcome Trust) Scientists have created mini biological models of human primary liver cancers, known as organoids, in the lab for the first time. In a paper published today in Nature Medicine, the tiny laboratory models of tumors were used to identify a new drug that could potentially treat certain types of liver cancer.

Cholera: The link between the world's major outbreaks leads to better control strategies

(Institut Pasteur) Researchers at the Institut Pasteur and the Wellcome Trust Sanger Institute, in collaboration with international institutions, recently published two studies tracing the history of cholera outbreaks from the last 60 years. Show More Summary

Risk of cholera epidemics estimated with new rule-book

(Wellcome Trust Sanger Institute) Cholera has repeatedly traveled out of Asia to cause epidemics in Africa and Latin America, an international research team has found. Researchers at the Wellcome Trust Sanger Institute, Institut Pasteur...Show More Summary

25 new genomes to celebrate 25 years of the Sanger Institute

To commemorate the Wellcome Trust Sanger Institute turning 25 in 2018, the Institute and its collaborators are sequencing 25 new genomes. From the blackberry to the robin, bush cricket to brown trout, the 25 species all reside in the UK and represent the richness of species in this country. Show More Summary

25 new genomes to celebrate 25 years of the Sanger Institute

(Wellcome Trust Sanger Institute) To commemorate the Wellcome Trust Sanger Institute turning 25 in 2018, the Institute and its collaborators are sequencing 25 new genomes. From the blackberry to the robin, bush cricket to brown trout, the 25 species all reside in the UK and represent the richness of species in this country. Show More Summary

Five new malaria targets that could lead to an effective vaccine

In the largest study of its kind, five new malaria vaccine targets have been discovered by scientists at the Wellcome Trust Sanger Institute and their collaborators. Researchers studied the malaria parasite at its most vulnerable stage - when invading human red blood cells - and identified five targets that lead to a reduction in the parasite's ability to enter red blood cells.

One to 10 mutations are needed to drive cancer, scientists find

(Wellcome Trust Sanger Institute) For the first time, scientists have provided unbiased estimates of the number of mutations needed for cancers to develop, in a study of more than 7,500 tumors across 29 cancer types. Researchers from...Show More Summary

Yeast spotlights genetic variation's link to drug resistance

Researchers have shown that genetic diversity plays a key role in enabling drug resistance to evolve. Scientists at the Wellcome Trust Sanger Institute and the Institute for Research on Cancer and Ageing of Nice in France, show that high genetic diversity can prime new mutations that cause drug resistance. Show More Summary

New drug hope for rare bone cancer patients

Patients with a rare bone cancer of the skull and spine - chordoma - could be helped by existing drugs, suggest scientists from the Wellcome Trust Sanger Institute, University College London Cancer Institute and the Royal National Orthopaedic Hospital NHS Trust. Show More Summary

New drug hope for rare bone cancer patients

(Wellcome Trust Sanger Institute) Patients with a rare bone cancer of the skull and spine -- chordoma -- could be helped by existing drugs, suggest scientists from the Wellcome Trust Sanger Institute, University College London Cancer Institute and the Royal National Orthopaedic Hospital NHS Trust. Show More Summary

New type of stem cell line produced offers expanded potential for research and treatments

Researchers at the Wellcome Trust Sanger Institute and their collaborators have created Expanded Potential Stem Cells (EPSCs) in mice, for the first time, that have a greater potential for development than current stem cell lines. These stem cells have the features of the very first cells in the developing embryo, and can develop into any type of cell.

Huge genetic diversity among Papuan New Guinean peoples revealed

The first large-scale genetic study of people in Papua New Guinea has shown that different groups within the country are genetically highly different from each other. Scientists at the Wellcome Trust Sanger Institute and their colleagues...Show More Summary

Immunotherapy treatment option for selected breast cancer patients, genetic study suggests

(Wellcome Trust Sanger Institute) Immunotherapy drugs could help some breast cancer patients based on the genetic changes in their tumors, researchers at the Wellcome Trust Sanger Institute and their collaborators find. Published today in Cancer Research, scientists identify particular genetic changes in a DNA repair mechanism in breast cancer. Show More Summary

Type 2 diabetes is being misdiagnosed in African-Americans, genetic study suggests

One of the tests used to diagnose type 2 diabetes and monitor blood sugar control is influenced by 60 genetic variants, an international team of scientists, including those from the Wellcome Trust Sanger Institute, has found. One genetic...Show More Summary

20,000 international voices share how they want their DNA information used

(Wellcome Trust Sanger Institute) The Wellcome Genome Campus and Global Alliance for Genomics and Health (GA4GH) have gone global with a project to explore public attitudes and beliefs on the sharing of genetic information. Now available...Show More Summary

Bowel cancer study reveals impact of mutations on protein networks

(Wellcome Trust Sanger Institute) For the first time, scientists have completed a detailed study of many of the proteins in bowel cancer cells. Scientists from the Wellcome Trust Sanger Institute investigated the role proteins play in...Show More Summary

New study reveals late spread of breast cancer and backs key role of early diagnosis

(Wellcome Trust Sanger Institute) Breast cancer cells that spread to other parts of the body break off and leave the primary tumor at late stages of disease development, scientists from the Wellcome Trust Sanger Institute and their collaborators have found. Show More Summary

Present-day Lebanese descend from Biblical Canaanites, genetic study suggests

In the most recent whole-genome study of ancient remains from the Near East, Wellcome Trust Sanger Institute scientists and their collaborators sequenced the entire genomes of 4,000-year-old Canaanite individuals who inhabited the region during the Bronze Age, and compared these to other ancient and present-day populations. Show More Summary

CARB-X funding for global scientists racing to discover new antibiotics to treat superbugs

(Wellcome Trust) CARB-X partnership announces funding for global scientists racing to discover new antibiotics. Scientists in India, Ireland, France, Switzerland, the US and UK are to share up to US$17.6m to speed treatments drug-resistant infections. Show More Summary

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